5-(3,3-dimethylguanidino)-2-oxopentanoate

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)

Catalysed by AGXT2, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

Catalysed by AGXT2

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. D-serine = pyruvate + NH4(+)

Catalysed by AGXT2, SRR

1. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
2. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)

Catalysed by AGXT2, GPTcytosol

1. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

Catalysed by AGXT2, AADAT

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. (R)-Lactate:NAD+ oxidoreductase

Catalysed by AGXT2, LDHDcytosol

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. (S)-Lactate:NAD+ oxidoreductase

Catalysed by AGXT2, LDHB, LDHAL6Bmitochondrial matrixOne of 5 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. 2-iminopropanoate + H2O = pyruvate + NH4(+)

Catalysed by AGXT2, RIDA

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. pyruvate kinase (dTDP)

Catalysed by AGXT2, PKM, PKLRcytosolOne of 3 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

Catalysed by AGXT2, NPLcytosol

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)

Catalysed by AGXT2, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

Catalysed by AGXT2, FAHD1

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

Catalysed by AGXT2One of 16 routes

1. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

Catalysed by AGXT2, AADAT

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

Catalysed by AGXT2, MPST

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

Catalysed by AGXT2

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

Catalysed by AGXT2, TYW1B, TYW1

1. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
2. L-threonine = 2-oxobutanoate + NH4(+)

Catalysed by AGXT2, SDS, SDSL

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by AGXT2mitochondrial matrixOne of 19 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase

Catalysed by AGXT2, DDAH1cytosolOne of 2 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

Catalysed by AGXT2One of 3 routes

1. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O

Catalysed by AGXT2, KYAT3, AADATOne of 4 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

Catalysed by AGXT2One of 3 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

Catalysed by AGXT2, CLYBL

1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
2. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

Catalysed by AGXT2, PCK1, PCK2

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

Catalysed by AGXT2One of 2 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Catalysed by AGXT2, HOGA1One of 2 routes

1. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

Catalysed by AGXT2, KYAT3, AADAT

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Catalysed by AGXT2, HOGA1One of 2 routes

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate

Catalysed by AGXT2One of 6 routes

1. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
2. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

Catalysed by AGXT2, RIDA

1. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

Catalysed by AGXT2, CLYBL

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

Catalysed by AGXT2, PDHA1, PDHB, PDHA2mitochondrial matrix

1. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH + H(+)

Catalysed by AGXT2, AADAT, MDH1

1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
3. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate