N-carbamoyl-beta-alanine

Three steps

• 6-amino-2-oxohexanoateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and lysine (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by SLC6A14extracellular space, cytosol, peroxisome

• L-homocysteineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC6A14, BHMT2extracellular space, cytosol

• carbamoyl phosphateReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Glutamine by Atb0 Transporter
  3. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

  Catalysed by SLC6A14, CADextracellular space, cytosolOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. ATP:sulfate adenylyltransferase

  Catalysed by SLC26A6, PAPSS1, PAPSS2extracellular space, cytosolOne of 4 routes

• N,N-dimethylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of betaine and chloride (cytosol to extracellular)
  3. L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine

  Catalysed by SLC6A12, BHMTextracellular space, cytosol

• S-methyl-L-methionineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC6A14, BHMT2extracellular space, cytosol

• L-tyrosineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by UPB1, GADL1, CSAD, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by UPB1, AGXT2cytosolOne of 7 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by UPB1, AGXT2, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• histamineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine carboxy-lyase (histamine-forming)

  Catalysed by SLC6A14, HDCextracellular space, cytosol

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by UPB1, GADL1, CSAD, PAICScytosolOne of 2 routes

• anserineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)
  3. carnosine + S-adenosyl-L-methionine = anserine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by UPB1, CARNS1, CARNMT1cytosol

• L-thyroxineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and iodide (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by SLC26A4, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• 5-guanidino-2-oxopentanoateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by SLC6A14, IL4I1extracellular space, cytosol

• S-sulfanyl-L-cysteineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLC6A14, CARS2extracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC6A14, IDO1, TDO2, IDO2extracellular space, cytosol

• 5-phospho-beta-D-ribosylamineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Glutamine by Atb0 Transporter
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by SLC6A14, PPATextracellular space, cytosolOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Glutamine by Atb0 Transporter
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by SLC6A14, GFPT2, GFPT1extracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC6A14, MSRAextracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC6A14, MSRB3, MSRB1, MSRB2extracellular space, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by UPB1, GATM, AGXT2cytosolOne of 2 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SLC6A14, PPCSextracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. thyroid peroxidase (iodine)

  Catalysed by SLC6A14, TPOextracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by UPB1, AGXT2, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• estrone 3-sulfateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by SLC26A6, STSextracellular space, cytosol

• N-benzoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by SLC6A9, SLC6A14extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by UPB1, GADL1, CSAD, SLC25A12 and 1 morecytosol, mitochondrial matrixOne of 6 routes

• L-cysteinylglycineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. gamma-glutamyltransferase (alanine)

  Catalysed by UPB1, AGXT2, GGTLC3, GGT1 and 4 morecytosolOne of 2 routes

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  3. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase

  Catalysed by CLTRN, SLC6A20, PYCR1, PYCR3 and 1 moreextracellular space, cytosolOne of 4 routes

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SLC26A6, SLC4A1extracellular space, cytosolOne of 2 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by SLC6A14, NOS3, NOS1, NOS2extracellular space, cytosol

• Mo-molybdopterinReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by UPB1, AGXT2, MOCOScytosol

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulum

• (2S)-2-aminobutanoateReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by UPB1, AGXT2cytosolOne of 2 routes

• O-dodecanoyl-R-carnitineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)

  Catalysed by SLC6A14, CPT1A, CPT1C, CPT1Bextracellular space, cytosolOne of 7 routes

• thio-Mo-molybdopterinReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC6A14, MOCOSextracellular space, cytosol

• glycodeoxycholateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC6A9, SLC6A14extracellular space, cytosolOne of 2 routes

• O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by SLC6A14, CRAT, CROTextracellular space, cytosol, peroxisomeOne of 5 routes

• N-tetradecanoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-eicosanoylglycinateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, BAATextracellular space, cytosol

• N-docosanoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, BAATextracellular space, cytosol

• N-hexacosanoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, BAATextracellular space, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Glutamine by Atb0 Transporter
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by SLC6A14, GLYATL1B, GLYATL1extracellular space, cytosol

• taurochenodeoxycholateReach from here →
  1. Transport of 3-Ureidopropionate
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase

  Catalysed by SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 3 routes