CHEBI:18132

Three steps

• (5Z)-octenoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by PHOSPHO1, SLC5A7, SLC6A5cytosol, extracellular spaceOne of 2 routes

• hypochlorous acidReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Peroxidase

  Catalysed by PHOSPHO1, SLC5A7, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 2 routes

• CHEBI:27540Reach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PHOSPHO1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PHOSPHO1, CHAT, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 7 routes

• a fatty acidReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 6 morecytosol

• a carboxylateReach from here →
  1. Phosphocholine phosphohydrolase
  2. an acylcholine + H2O = a carboxylate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by PHOSPHO1, BCHEcytosol

• hydrogenselenideReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by PHOSPHO1, CHDH, SCLYcytosol

• acetateReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  3. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 5 morecytosolOne of 8 routes

• formic acidReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC26A4cytosol, extracellular spaceOne of 2 routes

• malonic acidReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by PHOSPHO1, SLC5A7cytosol, extracellular spaceOne of 2 routes

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 6 morecytosolOne of 6 routes

• fatty acidReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 18 morecytosol, endoplasmic reticulumOne of 6 routes

• 25-hydroxycholesterolReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by PHOSPHO1, CHDH, CH25Hcytosol

• taurineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PHOSPHO1, CHAT, BAATcytosolOne of 4 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by PHOSPHO1, CHDH, RETSATcytosol

• an N-acylsphing-4-enineReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. ceramide cholinephosphotransferase (CDP-choline)

  Catalysed by PCYT1A, PCYT1Bcytosol, endoplasmic reticulumOne of 9 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO2cytosol

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO3cytosol

• glycineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PHOSPHO1, CHAT, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 13 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by PHOSPHO1, CHAT, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by PHOSPHO1, CHATcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PHOSPHO1, CHAT, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PHOSPHO1, CHATcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PHOSPHO1, CHAT, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PHOSPHO1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by PHOSPHO1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by PHOSPHO1, CHAT, SUCLG1, SUCLG2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PHOSPHO1, CHAT, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by PHOSPHO1, CHATcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 5 morecytosolOne of 15 routes

• prostaglandin H2Reach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by PHOSPHO1, CHDH, PTGS1, PTGS2cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by PHOSPHO1, CHDH, TBXAS1, PTGS2 and 1 morecytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol

  Catalysed by PCYT1A, PCYT1B, SGMS1, SGMS2cytosol, endoplasmic reticulum

• guanidinoacetateReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by PHOSPHO1, SLC5A7cytosol, extracellular space

• sphing-4-enineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PHOSPHO1, CHAT, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by PHOSPHO1, CHAT, SAT1, SAT2cytosolOne of 3 routes

• L-methionineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by PHOSPHO1, CHAT, NAGScytosol, mitochondrial matrixOne of 7 routes

• L-tryptophanReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• beta-alanineReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by PHOSPHO1, CHATcytosol, mitochondrial matrixOne of 5 routes

• L-asparagineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by PHOSPHO1, CHAT, NAGScytosol, mitochondrial matrixOne of 3 routes

• L-phenylalanineReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes