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Proteins/UNIPROT:P19971

TYMP

Protein·UNIPROT:P19971

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May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro..

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Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis..

Function from UniProtKB (P19971), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

mitochondrial disease has a germline basis in TYMPDiseaseGenCC HGNC:3148|MONDO:0044970Inferred only
mitochondrial DNA depletion syndrome 1 has a germline basis in TYMPDiseaseGenCC HGNC:3148|MONDO:0011283Inferred only
mitochondrial neurogastrointestinal encephalomyopathy has a germline basis in TYMPDiseaseGenCC HGNC:3148|MONDO:0017575Inferred only

Statements

2 statements

2 statements · 1 reference database · Subject: TYMP · Sources: Hetionet

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TYMP interacts with HSP90AA1ProteinHetionet hetionet:interacts:1890-3320Inferred only
TYMP interacts with UBCProteinHetionet hetionet:interacts:1890-7316Inferred only

Reactions

2 reactions

MAM00639c+MAM02997cphosphate(3-)+thymidine
Catalysed by TYMP
Reaction pageReversibleBalancedEC 2.4.2.1, 2.4.2.4GO:0005829
Human-GEM MAR04485CC BY 4.0Reference data
thymidine+hydrogenphosphate2-deoxy-alpha-D-ribose 1-phosphate+CHEBI:17821
Catalysed by TYMP
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16037CC BY 4.0Reference data

Other names

6 names

Resolves to: TYMP

Also called: ECGF1GliostatinPD-ECGFPlatelet-derived endothelial cell growth factorTdRPaseTP

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