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Reference

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7,8-dihydroneopterin

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

4 compounds within 3 steps: 1 in 1, 2 in 2, 1 in 3

Does it reach a compound?

One step

7,8-dihydroneopterin 3'-triphosphateReach from here →
1. alkaline phosphatase, biomineralization associated
Catalysed by ALPLextracellular space

Two steps

6-pyruvoyl-5,6,7,8-tetrahydropterinReach from here →
1. alkaline phosphatase, biomineralization associated
2. 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate + H(+)
Catalysed by ALPL, PTSextracellular space
triphosphateReach from here →
1. alkaline phosphatase, biomineralization associated
2. 6-pyruvoyltetrahydropterin synthase
Catalysed by ALPL, PTSextracellular space, cytosolOne of 3 routes

Three steps

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
Catalysed by ALPL, PTS, SPRextracellular space