3,3'-diiodo-L-thyronine

Three steps

• L-glutamineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 5 routes

• CHEBI:18095Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by DIO3, SLC26A4, CLTRN, SLC6A20extracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by DIO3, SLC26A4extracellular space, cytosolOne of 2 routes

• 3',5'-diiodo-L-thyronineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by DIO3, AIFM1, PYROXD1

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by DIO3, D2HGDH, AGXT2

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. formaldehyde to 5,10-methylene-THF conversion

  Catalysed by DIO3, KDM1A, KDM1Bcytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

  Catalysed by DIO3, MTO1, DHFR, DHFR2cytosolOne of 3 routes

• S-disulfanyl-L-cysteineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by DIO3, MOCOS, CARS2

• 3-iodothyronamineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by DIO3, AIFM1, PYROXD1, DIO1One of 2 routes

• thyronamineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by DIO3, AIFM1, PYROXD1

• 3'-iodothyronamineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by DIO3, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by DIO3, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by DIO3, AIFM1, PYROXD1

• 3,3',5'-triiodothyronamineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by DIO3, AIFM1, PYROXD1

• CHEBI:240943Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by DIO3, SLC26A4, SLC6A5extracellular space, cytosolOne of 2 routes

• hypochlorous acidReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Peroxidase

  Catalysed by DIO3, SLC26A4, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by DIO3, SLC26A4, SLC12A2, SLC12A1extracellular space, cytosolOne of 2 routes

• folic acidReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. Folate Transport by Oats

  Catalysed by STS, SLC22A8, SLC22A7Golgi apparatus, extracellular space, cytosolOne of 4 routes

• 5(S)-HETEReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 10 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:28666Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• N-acetyl-L-cysteineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by DIO3, MOCOS, NAGSmitochondrial matrix

• a dicarboxylateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by STS, SLC25A35, SLC25A34Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by DIO3, MOCOS, SLC1A1inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by DIO3, MOCOS, CARS1cytosol

• hydrogenselenideReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by DIO3, AIFM1, PYROXD1, SCLY

• glycocholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• cholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• hydrogen sulfideReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by DIO3, MOCOS, CTHcytosolOne of 2 routes

• D-aspartateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 7 routes

• oxalateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC26A2, SLC25A30 and 2 moreGolgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by DIO3, SLC26A4extracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by DIO3, D2HGDH, CSmitochondrial matrixOne of 2 routes

• maleateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by STS, SLC25A10Golgi apparatus, mitochondrial matrix, cytosolOne of 4 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by DIO3, D2HGDH, GOT2mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• thiosulfateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 1 moreGolgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• di-mu-sulfido-diiron(2+)Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. De novo synthesis of 2Fe2S

  Catalysed by DIO3, MOCOS, NDUFAB1, FDXR and 5 moremitochondrial matrix

• serotoninReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• chenodeoxycholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• taurocholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• glycolithocholic acidReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• 25-hydroxycholesterolReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, CH25H

• all-trans-4-oxoretinolReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. cytochrome P450 (retinol)

  Catalysed by DIO3, RETSAT, CYP26A1cytosol

• phosphoenolpyruvic acidReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by DIO3, D2HGDH, PCK1cytosolOne of 2 routes