3,3'-diiodo-L-thyronine

Three steps

• 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• 2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by DIO3, AIFM1, PYROXD1, PTGS2

• all-trans-retinyl tetradecanoateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

  Catalysed by DIO3, RETSAT, AWAT2

• an aryl sulfateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by STS, ARSL, ARSF, ARSK and 3 moreGolgi apparatus

• cholineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by DIO3, SLC26A4, SLC5A7extracellular space, cytosol

• acetylcholineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• pyruvateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by DIO3, MOCOS, CTHcytosolOne of 6 routes

• (S)-malateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. transport of malate and sulfate (cytosol to mitochondria)

  Catalysed by STS, SLC25A10Golgi apparatus, mitochondrial matrix, cytosolOne of 9 routes

• L-leucineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and leucine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A9, SLC3A1extracellular space, cytosolOne of 5 routes

• CHEBI:15650Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• all-trans-3-hydroxyretinolReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

  Catalysed by DIO3, RETSAT, CYP27C1

• CHEBI:15699Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and homoserine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 3 routes

• formateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)

  Catalysed by DIO3, KDM1A, KDM1B, ALDH9A1

• malonateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30, SLC25A10Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• bromideReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 18 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15971Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and histidine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A6extracellular space, cytosolOne of 3 routes

• methanethiolReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by DIO3, KDM1A, KDM1B, SELENBP1

• L-cystineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. thioredoxin-disulfide reductase (NADPH) (cystine)

  Catalysed by DIO3, MOCOS, TXNRD1, TXNRD3 and 1 morecytosolOne of 4 routes

• 11-cis-retinolReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by DIO3, RETSATcytosolOne of 2 routes

• cob(II)alaminReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by DIO3, AIFM1, PYROXD1, MTRR

• lithocholic acidReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• L-citrullineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes

• L-valineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes

• L-arginineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A6extracellular space, cytosolOne of 7 routes

• nitric oxideReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

  Catalysed by DIO3, AIFM1, PYROXD1, SUOX

• protein polypeptide chainReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. PROTEIN_BS

  Catalysed by DIO3, MOCOScytosol

• quinolinic acidReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. Transport of Quinolinic Acid

  Catalysed by STS, SLC22A6Golgi apparatus, extracellular space, cytosolOne of 2 routes

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by DIO3, AIFM1, PYROXD1, RSAD2

• (S)-2-hydroxyglutarateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by DIO3, AIFM1, PYROXD1, L2HGDH

• CHEBI:16857Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes

• bilirubin IXalphaReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• oxalic acidReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by STS, SLC26A6Golgi apparatus, extracellular space, cytosolOne of 2 routes

• taurolithocholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• L-isoleucineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes

• CHEBI:17203Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes

• CHEBI:17208Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular space

• homocysteineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Formation of Homocystine

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular space

• 5'-deoxyadenosineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by DIO3, AIFM1, PYROXD1, CDK5RAP1One of 4 routes

• sulfiteReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. Lecithin Retinol Acyltransferase

  Catalysed by DIO3, RETSAT, LRATcytosol

• all-trans-retinyl hexadecanoateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA

  Catalysed by DIO3, RETSAT, DGAT1, PNPLA4 and 3 moreOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by DIO1, DIO3, DIO2, SULT1A3 and 2 morecytosol

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by DIO3, AIFM1, PYROXD1, DIO1

• CHEBI:17724Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by DIO3, KDM1A, KDM1B, PDPR and 1 morecytosol

• glycine betaineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. choline + A = betaine aldehyde + AH2
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by DIO3, CHDH, ALDH7A1cytosolOne of 7 routes

• CHEBI:17895Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes

• all-trans-retinalReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol: NADP+ oxidoreductase

  Catalysed by DIO3, RETSAT, DHRS3, RDH10 and 4 morecytosolOne of 6 routes

• fumaric acidReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. transport of fumarate and sulfate (cytosol to mitochondria)

  Catalysed by STS, SLC25A10Golgi apparatus, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:18019Reach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A6extracellular space, cytosolOne of 3 routes

• a diacylglycerolReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol

  Catalysed by DIO3, RETSAT, PNPLA4, PNPLA2