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Proteins/UNIPROT:Q4G0S4
[Isoform 2]: A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)..
Function from UniProtKB (Q4G0S4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · metabolized by
1 compound
1 compound.
0 reported routes1 assembled route
40 statements
40 statements · 4 reference databases · Subject: CYP27C1 · Sources: Hetionet, Rhea, UniProt, WikiPathways
3 reactions
all-trans-retinol+2reduced [adrenodoxin]+dioxygen+2hydronall-trans-3,4-didehydroretinol+2oxidized [adrenodoxin]+2water
Catalysed by CYP27C1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50292CC BY 4.0Reference data
all-trans-retinol+2reduced [adrenodoxin]+dioxygen+2hydron
1 name
Resolves to: CYP27C1
Catalysed by CYP27C1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50300CC BY 4.0Reference data
all-trans-retinol+2reduced [adrenodoxin]+dioxygen+2hydronall-trans-3-hydroxyretinol+2oxidized [adrenodoxin]+water
Catalysed by CYP27C1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:65520CC BY 4.0Reference data