S-methyl-5'-thioadenosine

Three steps

• N(2)-acetyl-L-ornithineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. L-ornithine + H(+) = putrescine + CO2
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SRM, ODC1, ACY1cytosol

• CHEBI:16857Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and threonine (cytosol to extracellular)

  Catalysed by SRM, SLC3A2, SLC7A7, SLC7A6extracellular space, cytosolOne of 4 routes

• L-isoleucineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and isoleucine (cytosol to extracellular)

  Catalysed by SRM, SLC3A2, SLC7A7, SLC7A6extracellular space, cytosolOne of 4 routes

• CHEBI:17202Reach from here →
  1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
  2. Adenine aminohydrolase
  3. IMP:diphosphate phospho-D-ribosyltransferase

  Catalysed by MTAP, HPRT1cytosol

• CHEBI:17203Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and proline (cytosol to extracellular)

  Catalysed by SRM, SLC3A2, SLC7A7, SLC7A6extracellular space, cytosolOne of 4 routes

• L-glutamic 5-semialdehydeReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. L-ornithine + H(+) = putrescine + CO2
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by SRM, ODC1, OATmitochondrial matrix

• anilineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SRM, SAT1, SAT2, NAT2 and 1 morecytosol

• CHEBI:17312Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SRM, SAT1, SAT2cytosolOne of 2 routes

• agmatineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SRM, SLC3A2, SLC7A7extracellular space, cytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SRM, SAT1, SAT2, NAGScytosol, mitochondrial matrixOne of 8 routes

• inosineReach from here →
  1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
  2. adenosine:phosphate alpha-D-ribosyltransferase
  3. Adenosine aminohydrolase

  Catalysed by MTAP, PNP, ADA, ADA2cytosolOne of 7 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SRM, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrix

• xanthineReach from here →
  1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
  2. Adenine aminohydrolase
  3. hypoxanthine:NAD+ oxidoreductase

  Catalysed by MTAP, XDHcytosolOne of 4 routes

• CHEBI:17895Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and tyrosine (cytosol to extracellular)

  Catalysed by SRM, SLC3A2, SLC7A7, SLC7A6extracellular space, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SRM, SAT1, SAT2cytosolOne of 4 routes

• CHEBI:18019Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and lysine (cytosol to extracellular)

  Catalysed by SRM, SLC3A2, SLC7A7, SLC7A5 and 1 moreextracellular space, cytosolOne of 8 routes

• L-glutamineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and glutamine (cytosol to extracellular)

  Catalysed by SRM, SLC3A2, SLC7A7, SLC7A6extracellular space, cytosolOne of 7 routes

• N-(4-aminobutyl)-3-aminopropanalReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase
  3. primary-amine oxidase (spermidine)

  Catalysed by SRM, AOC2, AOC1, AOC3cytosolOne of 3 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SRM, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SRM, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SRM, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SRM, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SRM, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SRM, SAT1, SAT2, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SRM, SAT1, SAT2, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SRM, SAT1, SAT2, ACSM4 and 5 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SRM, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SRM, SAT1, SAT2, ACAA1 and 2 morecytosol, peroxisomeOne of 7 routes

• CHEBI:28862Reach from here →
  1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
  2. adenosine:phosphate alpha-D-ribosyltransferase
  3. Adenosine Kinase

  Catalysed by MTAP, PNPcytosol

• 2'-deoxyinosineReach from here →
  1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
  2. Deoxyadenosine:orthophosphate ribosyltransferase
  3. deoxyadenosine aminohydrolase

  Catalysed by MTAP, PNP, ADA, ADA2cytosolOne of 5 routes

• chlorine(.)Reach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SRM, SLC3A2, SLC7A7, SLC6A14extracellular space, cytosolOne of 2 routes

• acetateReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by SRM, SAT1, SAT2, HDAC10cytosol

• 3-acetamidopropanalReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  3. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2

  Catalysed by SRM, PAOX

• L-lysineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by SRM, SLC3A2, SLC7A7, SLC7A9 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• D-lysineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. L-ornithine + H(+) = putrescine + CO2
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SRM, ODC1, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• D-arginineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. L-ornithine + H(+) = putrescine + CO2
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SRM, ODC1, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• D-ribose 1-phosphateReach from here →
  1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
  2. adenosine:phosphate alpha-D-ribosyltransferase
  3. adenosine:phosphate alpha-D-ribosyltransferase

  Catalysed by MTAP, PNPcytosol

• taurineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SRM, SAT1, SAT2, BAATcytosolOne of 2 routes

• glycineReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by SRM, SAT1, SAT2, GLYAT and 2 morecytosol, mitochondrial matrixOne of 16 routes

• (R)-methylmalonyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SRM, SAT1, SAT2, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SRM, SAT1, SAT2cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SRM, SAT1, SAT2, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SRM, SAT1, SAT2cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SRM, SAT1, SAT2, ACAA1 and 1 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SRM, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SRM, SAT1, SAT2, ACSM4 and 5 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SRM, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by SRM, SAT1, SAT2, CPT1A and 2 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SRM, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SRM, SAT1, SAT2, SUCLG1 and 2 morecytosol, mitochondrial matrixOne of 2 routes