CHEBI:17380

Three steps

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by KYNU, AGXT2, PAICScytosolOne of 2 routes

• 5-guanidino-2-oxopentanoateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. transport of alanine and arginine (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by KYNU, SLC7A6, IL4I1cytosol, extracellular space

• (3Z)-dodecenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by KYNU, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

• S-sulfanyl-L-cysteineReach from here →
  1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by KMO, AADAT, CARS2cytosol

• (3S)-citramalyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by KYNU, AGXT2, CLYBLcytosol, mitochondrial matrix

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by KYNU, SLC27A2, SLC27A5cytosol, mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. transport of alanine and glutamine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by KYNU, SLC3A2, SLC7A5, SLC7A10 and 1 morecytosol, extracellular spaceOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. transport of alanine and glutamine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by KYNU, SLC3A2, SLC7A5, SLC7A10 and 2 morecytosol, extracellular space

• L-methionine (S)-S-oxideReach from here →
  1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  2. 4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by KMO, AADAT, MSRAcytosol

• L-methionine (R)-S-oxideReach from here →
  1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  2. 4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by KMO, AADAT, MSRB3, MSRB1 and 1 morecytosol

• 5-amino-2-oxopentanoateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by KYNU, AGXT2cytosol, mitochondrial matrixOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by KYNU, SLC27A2, SLC27A5cytosol, mitochondrial matrixOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by KMO, KYAT3, AADAT, GLYATL2cytosolOne of 2 routes

• methylamineReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
  3. N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine

  Catalysed by KYNU, AGXT2, DDAH1cytosol

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by KMO, AADAT, PPCScytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Transport of 3-Hydroxy-L-Kynurenine
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 3 routes

• pyridoxal 5'-phosphateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2

  Catalysed by KYNU, SCLY, PNPOcytosol

• an N-acyl-L-amino acidReach from here →
  1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  2. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)
  3. an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate

  Catalysed by KMO, SLC7A11, ACY1, PM20D1cytosol, inner side of the membrane, outer side of the membrane

• 4-aminobutanoateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. transport of alanine and chloride (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by KYNU, SLC6A14, SLC6A12cytosol, extracellular spaceOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. transport of alanine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by KYNU, SLC7A5, TPOcytosol, extracellular spaceOne of 2 routes

• N-benzoylglycineReach from here →
  1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by KMO, KYAT3, AADATcytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by KMO, AADAT, CDO1cytosolOne of 6 routes

• decanoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by KYNU, ACSM4, ACSM1, ACSM2A and 3 morecytosol, mitochondrial matrixOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by KYNU, CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 11 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by KYNU, AGXT2, HOGA1cytosol, mitochondrial matrix

• 3-hydroxyisovaleryl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by KYNU, CPT1A, CPT1Bcytosol, mitochondrial matrix

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. Transport of Hydroxy-Proline
  3. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase

  Catalysed by KYNU, SLC1A4, PYCR1, PYCR3 and 1 morecytosol, extracellular spaceOne of 5 routes

• CHEBI:63544Reach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 10 routes

• docosanoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 9 routes

• a 2,3-saturated acyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by KYNU, MOCOS, ACAD10cytosol

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. transport of alanine and arginine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by KYNU, SLC7A6, NOS3, NOS1 and 1 morecytosol, extracellular space

• (2E)-octadecenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by KYNU, CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by KYNU, AGXT2, HOGA1cytosol, mitochondrial matrix

• L-threonylcarbamoyladenylateReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
  3. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O

  Catalysed by KYNU, SLC7A10, YRDCcytosol, inner side of the membrane, outer side of the membrane

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. 3-Hydroxy-L-kynurenine hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by KYNU, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 7 routes