(8Z,11Z,14Z)-eicosatrienoyl-CoA

1. Dihomo-gamma-linolenoyl-CoA hydrolase

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 8 routes

1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)

Catalysed by FADS1cytosolOne of 2 routes

1. Beta Oxidation of Fatty Acid

Catalysed by ACADM, ACADSmitochondrial matrix

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Catalysed by FADS1

1. acyl-CoA pool formation and breakdown

No catalyst recordedcytosol

1. Dihomo-gamma-linolenoyl-CoA hydrolase

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol

1. ELOVL fatty acid elongase (trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA)

Catalysed by ELOVL1endoplasmic reticulumOne of 2 routes

1. Acyl-CoA:cholesterol O-acyltransferase

Catalysed by SOAT2, SOAT1endoplasmic reticulum

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Carnitine O-Palmitoyltransferase

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 245 routes

1. Acyl-CoA:cholesterol O-acyltransferase
2. Steryl-ester acylhydrolase

Catalysed by SOAT2, SOAT1, CEL, LIPAendoplasmic reticulum, lysosome