oxalic acid

Three steps

• S-methyl-L-methionineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC26A6, SLC6A14, BHMT2extracellular space, cytosol

• (2R)-2-phosphoglycerateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by SLC25A1, ENO1, ENO2, ENO3mitochondrial matrix, cytosolOne of 2 routes

• glutathione disulfideReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC26A6, SLC25A14, SLC25A30, SLC26A1 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-tyrosineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SLC26A6, SLC6A9, SLC6A14, AADATextracellular space, cytosolOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC26A6, SLC6A9, SLC6A14, AGXT2extracellular space, cytosolOne of 5 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC26A6, SLC6A14, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• histamineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine carboxy-lyase (histamine-forming)

  Catalysed by SLC26A6, SLC6A14, HDCextracellular space, cytosol

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC26A6, SLC25A10, ADSLextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• L-thyroxineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by SLC26A6, SLC26A4, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• kynurenateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-guanidino-2-oxopentanoateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by SLC26A6, SLC6A14, IL4I1extracellular space, cytosol

• S-sulfanyl-L-cysteineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLC26A6, SLC6A14, CARS2extracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC26A6, SLC6A14, IDO1, TDO2 and 1 moreextracellular space, cytosol

• 5-phospho-beta-D-ribosylamineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by SLC26A6, SLC6A14, PPATextracellular space, cytosolOne of 2 routes

• D-glucosamineReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC26A6, SGSHextracellular space, cytosol

• D-glucosamine 6-phosphateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by SLC26A6, SLC6A14, GFPT2, GFPT1extracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC26A6, SLC6A14, MSRAextracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC26A6, SLC6A14, MSRB3, MSRB1 and 1 moreextracellular space, cytosol

• S-sulfanylglutathioneReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by SLC26A6, SLC25A14, SLC25A30, ETHE1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SLC26A6, SLC6A14, PPCSextracellular space, cytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-iodo-L-tyrosineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. thyroid peroxidase (iodine)

  Catalysed by SLC26A6, SLC6A14, TPOextracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC26A6, SLC6A14, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by SLC26A6, SLC6A9, SLC6A14extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• 3-sulfino-L-alanineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by SLC26A6, SLC6A14, CDO1extracellular space, cytosolOne of 6 routes

• L-cysteinylglycineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC26A6, SLC6A14, GGTLC3, GGT1 and 4 moreextracellular space, cytosolOne of 2 routes

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  3. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase

  Catalysed by SLC26A6, CLTRN, SLC6A20, PYCR1 and 2 moreextracellular space, cytosolOne of 4 routes

• ubiquinol-10Reach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SLC26A6, SLC25A14, SLC25A30, SQORextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by SLC26A6, SLC6A14, NOS3, NOS1 and 1 moreextracellular space, cytosol

• Mo-molybdopterinReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC26A6, SLC6A14, MOCOSextracellular space, cytosol

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, endoplasmic reticulum

• (2S)-2-aminobutanoateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by SLC26A6, SLC6A9, SLC6A14, AGXT2extracellular space, cytosolOne of 2 routes

• O-dodecanoyl-R-carnitineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)

  Catalysed by SLC26A6, SLC6A14, CPT1A, CPT1C and 1 moreextracellular space, cytosolOne of 7 routes

• thio-Mo-molybdopterinReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC26A6, SLC6A14, MOCOSextracellular space, cytosol

• glycodeoxycholateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC26A6, SLC6A9, SLC6A14extracellular space, cytosolOne of 2 routes

• O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by SLC26A6, SLC6A14, CRAT, CROTextracellular space, cytosol, peroxisomeOne of 5 routes

• N-tetradecanoylglycineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-eicosanoylglycinateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, BAATextracellular space, cytosol

• N-docosanoylglycineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, BAATextracellular space, cytosol

• N-hexacosanoylglycineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, BAATextracellular space, cytosol

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. transport of oxalate and sulfate (cytosol to extracellular)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC26A6, STS, CYP3A7extracellular space, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A14, GLYATL1B, GLYATL1extracellular space, cytosol

• 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)
  3. aldehydo-D-mannose 6-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate

  Catalysed by SLC25A1, NANSmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• taurochenodeoxycholateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase

  Catalysed by SLC26A6, SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 3 routes