N-acetyl-L-aspartate

Three steps

• maleateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 1 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  3. (S)-dihydroorotate amidohydrolase

  Catalysed by ASPA, ACY3, CADcytosolOne of 2 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by ASPA, ACY3, GOT2cytosol, mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-lysineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by ASPA, ACY3, SLC7A13, SLC7A7cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• putrescineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-acetylputrescine + H2O = putrescine + acetate
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by ASPA, ACY3, HDAC10cytosol

• 3-oxopropanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• thiosulfateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by ASPA, ACY3, SLC7A13, IL4I1cytosol, inner side of the membrane, outer side of the membrane

• a phenolReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. a phenyl acetate + H2O = a phenol + acetate + H(+)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by ASPA, ACY3, PON1, PON2 and 1 morecytosol

• serotoninReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of aspartate (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by ASPA, ACY3, SLC1A7, SLC1A3 and 4 morecytosol, extracellular spaceOne of 2 routes

• D-cysteineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by ASPA, ACY3, AGXT2, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 11 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate

  Catalysed by ASPA, ACY3, SLC7A13, TATcytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• (R)-lactic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• 2-iminopropanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• phosphoenolpyruvic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 5 morecytosol, extracellular spaceOne of 3 routes

• 13-cis-retinalReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 3 morecytosol, extracellular space, endoplasmic reticulum

• N-acetyl-beta-neuraminic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• L-ornithineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N2-Acetyl-L-ornithine amidohydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by ASPA, ACY3, ACY1cytosolOne of 25 routes

• gamma-Glu-AlaReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. gamma-glutamyltransferase (alanine)

  Catalysed by ASPA, ACY3, AGXT2, GGT1 and 5 morecytosol, extracellular space

• taurineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ASPA, ACY3, NAT8L, BAATcytosol, mitochondrial matrixOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• acetoacetyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• glycineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, ASNScytosol, extracellular spaceOne of 57 routes

• (R)-methylmalonyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ASPA, ACY3, NAT8L, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ASPA, ACY3, NAT8Lcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ASPA, ACY3, NAT8L, ACP2cytosol, mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by ASPA, ACY3, NAT8Lcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ASPA, ACY3, NAT8L, ACAA1 and 1 morecytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 7 routes

• butanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and butyrate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 8 morecytosol, extracellular spaceOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 9 routes

• glutaryl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by ASPA, ACY3, NAT8L, CPT1A and 2 morecytosol, mitochondrial matrixOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 12 routes

• itaconyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ASPA, ACY3, NAT8L, SUCLG1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 11 routes

• octanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by ASPA, ACY3, NAT8L, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by ASPA, ACY3, NAT8Lcytosol, mitochondrial matrixOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 6 morecytosol, mitochondrial matrixOne of 15 routes

• D-alanineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by ASPA, ACY3, AGXT2, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• carnosineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by ASPA, ACY3, GAD2, CARNS1cytosol

• L-dopaReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by ASPA, ACY3, SLC7A13, SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes