lanosterol

Three steps

• L-arginineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of acetate and formate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

• (S)-lactateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 7 morecytosol, extracellular space

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)

  Catalysed by CYP51A1, ADI1

• 2-oxobutanoateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)
  3. 2-hydroxybutyrate:NAD+ oxidoreductase

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 5 morecytosol, extracellular spaceOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• CHEBI:16856Reach from here →
  1. lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
  2. S-formylglutathione + H2O = formate + glutathione + H(+)
  3. S-Formylglutathione hydrolase

  Catalysed by CYP51A1, ESDcytosolOne of 2 routes

• CHEBI:16857Reach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular space

• ferrocytochrome cReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and L-lactate (cytosol to extracellular)
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space, mitochondrial matrix

• oxalic acidReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by CYP4F8, SLC26A4, SLC26A6cytosol, extracellular space

• 3-hydroxypyruvateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• L-isoleucineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by CYP4F8, SLC26A4, CLTRN, SLC6A20cytosol, extracellular spaceOne of 2 routes

• COReach from here →
  1. lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. acireductone dioxygenase

  Catalysed by CYP51A1, ADI1cytosolOne of 2 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of acetate and formate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space, endoplasmic reticulum

• aceneuramateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• 5'-deoxyadenosineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 4 morecytosol, extracellular space

• L-cysteineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17724Reach from here →
  1. lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
  2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by CYP51A1, ALDH9A1, PDPR, DMGDHcytosol

• glycine betaineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by CYP4F8, SLC26A4, SLC6A12cytosol, extracellular spaceOne of 3 routes

• 4-methylumbelliferyl acetateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of acetate and formate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1 and 3 morecytosol, extracellular space

• urateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and L-lactate (cytosol to extracellular)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• CHEBI:17895Reach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

• all-trans-retinalReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by CYP4F8, SLC16A4, SLC16A5cytosol, extracellular space

• CHEBI:18019Reach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular space

• 4-fumarylacetoacetateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of acetoacetate and formate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, FAHcytosol, extracellular space

• L-glutamineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular space

• dTDPReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 4 morecytosol, extracellular space

• CHEBI:18095Reach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by CYP4F8, SLC26A4, CLTRN, SLC6A20cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by CYP4F8, SLC26A4cytosol, extracellular spaceOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by CYP4F8, MTHFD1, GARTcytosol

• CHEBI:18381Reach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by CYP4F8, MTHFD1, ATICcytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
  2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
  3. formaldehyde to 5,10-methylene-THF conversion

  Catalysed by CYP51A1, ALDH9A1cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:NADP+ oxidoreductase

  Catalysed by CYP4F8, MTHFD1, ALDH1L1, ALDH1L2cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by CYP4F8, SLC26A4, SLC6A5cytosol, extracellular spaceOne of 2 routes

• hypochlorous acidReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by CYP4F8, SLC26A4, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by CYP4F8, SLC26A4, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 2 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of acetate and formate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space, endoplasmic reticulum

• malonic acidReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by CYP4F8, SLC26A4cytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 2 routes

• 3-oxopropanoateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. Acireductone Dixoygenase 1

  Catalysed by CYP51A1, ADI1cytosol

• D-serineReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• (R)-lactic acidReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of acetoacetate and formate (cytosol to extracellular)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by CYP4F8, SLC16A4, SLC16A5, HMGCL and 1 morecytosol, extracellular space

• 2-iminopropanoateReach from here →
  1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space