L-arginine

1. transport of arginine and histidine (cytosol to extracellular)
2. L-histidine carboxy-lyase (histamine-forming)

Catalysed by SLC7A5, SLC7A6, HDCextracellular space, cytosolOne of 2 routes

1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)
2. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membrane

1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)
2. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membrane

1. transport of arginine and cysteine (cytosol to extracellular)
2. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

Catalysed by SLC7A6, CARS2extracellular space, cytosol

1. transport of arginine and tryptophan (cytosol to extracellular)
2. L-tryptophan + O2 = N-formyl-L-kynurenine

Catalysed by SLC7A6, IDO1, TDO2, IDO2extracellular space, cytosol

1. transport of arginine and glutamine (cytosol to extracellular)
2. phosphoribosyl pyrophosphate amidotransferase (glutamine)

Catalysed by SLC7A6, PPATextracellular space, cytosolOne of 2 routes

1. transport of arginine and glutamine (cytosol to extracellular)
2. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

Catalysed by SLC7A6, GFPT2, GFPT1extracellular space, cytosol

1. transport of arginine and methionine (cytosol to extracellular)
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

Catalysed by SLC7A6, MSRAextracellular space, cytosol

1. transport of arginine and methionine (cytosol to extracellular)
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

Catalysed by SLC7A6, MSRB3, MSRB1, MSRB2extracellular space, cytosol

1. L-Arginine amidinohydrolase
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

Catalysed by ARG1, AGXT2cytosolOne of 2 routes

1. transport of arginine and glycine (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by SLC7A6, GLYATL2extracellular space, cytosolOne of 2 routes

1. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
2. N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine

Catalysed by SLC25A29, DDAH1inner side of the membrane, outer side of the membrane

1. transport of arginine and cysteine (cytosol to extracellular)
2. (R)-4'-phosphopantothenate:L-cysteine ligase

Catalysed by SLC7A6, PPCSextracellular space, cytosolOne of 4 routes

1. transport of arginine and chloride (cytosol to extracellular)
2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

Catalysed by SLC6A14, SLC6A12extracellular space, cytosolOne of 5 routes

1. transport of arginine and tyrosine (cytosol to extracellular)
2. thyroid peroxidase (iodine)

Catalysed by SLC7A6, TPOextracellular space, cytosolOne of 2 routes

1. transport of alanine and arginine (cytosol to extracellular)
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by SLC7A6, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of arginine and glycine (cytosol to extracellular)
2. Hippurate (Benzoylglycinate) Formation

Catalysed by SLC7A6extracellular space, cytosol, mitochondrial matrixOne of 2 routes

1. transport of arginine and cysteine (cytosol to extracellular)
2. L-Cysteine:oxygen oxidoreductase

Catalysed by SLC7A6, CDO1extracellular space, cytosolOne of 2 routes

1. transport of alanine and arginine (cytosol to extracellular)
2. gamma-glutamyltransferase (alanine)

Catalysed by SLC7A6, GGTLC3, GGT1, GGT5 and 3 moreextracellular space, cytosolOne of 2 routes

1. transport of alanine and arginine (cytosol to extracellular)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A6, MOCOSextracellular space, cytosol

1. transport of arginine and glycine (cytosol to extracellular)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

Catalysed by SLC7A6, AGXT2extracellular space, cytosolOne of 3 routes

1. transport of arginine and cysteine (cytosol to extracellular)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A6, MOCOSextracellular space, cytosol

1. transport of arginine and glycine (cytosol to extracellular)
2. Glycodeoxycholate amidohydrolase

Catalysed by SLC7A6extracellular space, cytosolOne of 2 routes

1. transport of arginine and glycine (cytosol to extracellular)
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

1. transport of arginine and glycine (cytosol to extracellular)
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by SLC7A6, BAATextracellular space, cytosol

1. transport of arginine and glycine (cytosol to extracellular)
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by SLC7A6, BAATextracellular space, cytosol

1. transport of arginine and glycine (cytosol to extracellular)
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by SLC7A6, BAATextracellular space, cytosol

1. transport of arginine and glutamine (cytosol to extracellular)
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by SLC7A6, GLYATL1B, GLYATL1extracellular space, cytosol

1. transport of arginine and tyrosine (cytosol to extracellular)
2. L-tyrosine:2-oxoglutarate aminotransferase
3. (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH + H(+)

Catalysed by SLC7A6, GOT2, GOT1, TAT and 1 moreextracellular space, cytosol

1. transport of alanine and arginine (cytosol to extracellular)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)