iodide

Three steps

• citric acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC26A4, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• butyric acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of butyrate and formate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• maleateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• isocitric acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC26A4, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (2R,3R)-tartrateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z)-hexadecenoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 6 routes

• L-lysineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by SLC26A4, SLC6A14, SLC7A9, SLC25A29 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• putrescineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC26A4, SLC6A14, SLC3A2, SLC7A7extracellular space, cytosol

• cis-aconitic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC26A4, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 3-oxopropanoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC26A4, SLC6A6, SLC6A14, AGXT2extracellular space, cytosol

• thiosulfateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC26A4, SLC6A14, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC26A4, SLC6A14, NDUFAB1, FDXR and 5 moreextracellular space, cytosol, mitochondrial matrix

• serotoninReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 5 routes

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC26A4, SLC6A14, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC26A4, SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)

  Catalysed by SLC26A4, SLC6A14, SLC1A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• an acylcholineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by SLC26A4, SLC5A7, BCHEextracellular space, cytosol

• 5-aminolevulinateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC26A4, SLC6A9, SLC6A14, ALAS1 and 1 moreextracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC26A4, SLC6A14, BCAT1extracellular space, cytosolOne of 2 routes

• chenodeoxycholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC26A4, SLC6A14, GOT2, GOT1 and 1 moreextracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, BAATextracellular space, cytosol

• taurocholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 7 routes

• taurodeoxycholateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLC26A4, SLC6A6, BAATextracellular space, cytosolOne of 2 routes

• glycochenodeoxycholic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC26A4, SLC6A9, SLC6A14, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC26A4, SLC6A9, SLC6A14, AADATextracellular space, cytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GCATextracellular space, cytosol, mitochondrial matrix

• (S)-lactic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and L-lactate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

• L-ornithineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by SLC26A4, SLC6A6, GATMextracellular space, cytosolOne of 59 routes

• gamma-Glu-AlaReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 7 morecytosol, extracellular spaceOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLDC and 1 moreextracellular space, cytosol, mitochondrial matrix

• butanoyl-CoAReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)

  Catalysed by SLC26A4, SLC6A14, SLC33A1, ESCO2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• prostaglandin E1Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin I2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin H2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin D2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 10 morecytosol, extracellular space

• D-alanineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SLC26A4, SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLC26A4, SLC6A9, SLC6A14, PIPOXextracellular space, cytosolOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by DIO1, DIO3, DIO2, MTO1cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC26A4, SLC6A9, SLC6A14, SHMT1 and 1 moreextracellular space, cytosol

• leukotriene A4Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes