CHEBI:16108

Two steps

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by GNPAT, ECHS1, ACAA2, HADHperoxisome, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by GNPAT, ECHS1, ACAA2, HADHperoxisome, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 3 moreperoxisome, cytosolOne of 6 routes

• hydroxyacetoneReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. aldose reductase (methylglyoxal)

  Catalysed by AKR7A2, AKR1A1, AKR1B1cytosolOne of 2 routes

• elaidic acidReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by GNPAT, ACAA1, SCP2, MYO5BperoxisomeOne of 7 routes

• fatty acidReach from here →
  1. Acyl-CoA:glycerone-phosphate O-acyltransferase
  2. alkylglycerone phosphate synthase (acylglycerone-phosphate)

  Catalysed by GNPAT, AGPScytosol, peroxisome

• taurineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by GNPAT, BAATperoxisome, cytosolOne of 2 routes

• glycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1peroxisome, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by GNPAT, ALDH6A1peroxisome, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by GNPATperoxisome, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by GNPAT, ACP2peroxisome, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by GNPATperoxisome, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by GNPAT, ACAA1, MYO5BperoxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 3 moreperoxisome, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Production of Glutaryl Carnitine

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by GNPAT, SUCLG1, SUCLG2, SUCLA2peroxisome, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by GNPAT, CROTperoxisome, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. phytanate-CoA ligase

  Catalysed by GNPATperoxisome, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 4 moreperoxisome, cytosolOne of 15 routes

• (R)-S-lactoylglutathioneReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by GLO1, GLOD4cytosolOne of 2 routes

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by GPD1, GPD1L, GPAT3, GPAT2 and 2 morecytosolOne of 2 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate

  Catalysed by GNPAT, AGPSperoxisome

• (2R)-3-phospho-glyceroyl phosphateReach from here →
  1. D-glyceraldehyde-3-phosphate aldose-ketose-isomerase
  2. D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)

  Catalysed by TPI1, GAPDHS, GAPDHcytosol

• beta-D-fructose 6-phosphateReach from here →
  1. Alkaline Phosphatase
  2. beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate

  Catalysed by ALPL, ALPP, ALPI, ALPG and 1 morecytosol

• dihydroxyacetone phosphateReach from here →
  1. Alkaline Phosphatase
  2. dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 1 morecytosolOne of 2 routes

• sphing-4-enineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 1 moreperoxisome, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by GNPAT, SAT1, SAT2peroxisome, cytosolOne of 3 routes

• L-methionineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by GNPAT, NAGSperoxisome, mitochondrial matrix

• L-alanineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by GNPATperoxisome, mitochondrial matrix

• L-asparagineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by GNPAT, NAGSperoxisome, mitochondrial matrix

• glycerol 2-phosphateReach from here →
  1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  2. Formation of Glycerol-3-Phosphate

  Catalysed by GPD1, GPD1Lcytosol

• L,L-cystathionineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by GNPAT, NAGSperoxisome, mitochondrial matrix

• CDP-glycerolReach from here →
  1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  2. CDPglycerol phosphoglycerohydrolase

  Catalysed by GPD1, GPD1L, ADPRMcytosol

• an acyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 1 moreperoxisome, Golgi apparatusOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by GNPAT, HADHA, ACAA2, HADHBperoxisome, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by GNPAT, SLC27A2, SLC27A5peroxisome, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by GNPAT, SLC27A2, SLC27A5peroxisome, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 3 moreperoxisome, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Carnitine O-Palmitoyltransferase

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by GNPAT, CPT1A, CPT1Bperoxisome, cytosol

• CHEBI:63544Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 10 routes