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Proteins/UNIPROT:Q3LIE5
Hydrolyzes ADP-ribose, ADP, CDP-glycerol, CDP-choline, CDP-ethanolamine and cyclic ADP-ribose (cADPR), but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity)..
Function from UniProtKB (Q3LIE5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 5 reference databases · Subject: ADPRM · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt
10 reactions
CDP-glycerol+watercytidine 5'-monophosphate+2proton+CHEBI:15978
Catalysed by ADPRM
Reaction pageReversibleBalancedEC 3.6.1.16cytosol
Human-GEM MAR00484CC BY 4.0Reference data
ADP-D-ribose+waterAMP+2proton+CHEBI:17797
Catalysed by NUDT5
3 names
Resolves to: ADPRM
Reaction pageLeft to rightBalancedEC 3.6.1.13, 3.6.1.53cytosol
Human-GEM MAR07144CC BY 4.0Reference data
ADP-alpha-D-glucose+waterAMP+MAM01967c+2proton
Reaction pageLeft to rightBalancedEC 3.6.1.13cytosol
Human-GEM MAR08443CC BY 4.0Reference data
MAM01287c+waterAMP+2proton+MAM02454c
Reaction pageLeft to rightBalancedEC 3.6.1.13cytosol
Human-GEM MAR08444CC BY 4.0Reference data
ADP-D-ribose+waterD-ribose 5-phosphate+AMP+2hydron
Catalysed by NUDT14 or ADPRM or NUDT9 or NUDT5
Reaction pageLeft to rightBalanced
Rhea RHEA:10412CC BY 4.0Reference data
CDP-glycerol+watersn-glycerol 3-phosphate+CMP+2hydron
Catalysed by ADPRM
Reaction pageDirection not assertedBalanced
Rhea RHEA:21692CC BY 4.0Reference data
CDP-choline+waterphosphocholine+CMP+2hydron
Catalysed by ADPRM
Reaction pageDirection not assertedBalanced
Rhea RHEA:32487CC BY 4.0Reference data
ADP(3-)+waterAMP+hydrogenphosphate+hydron
Catalysed by ENTPD3 or ENTPD5 or ALPL or ENTPD1 or ADPRM or ENTPD8 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:61436CC BY 4.0Reference data
CDP-ethanolamine+waterphosphoethanolamine+CMP+2hydron
Catalysed by ADPRM
Reaction pageDirection not assertedBalanced
Rhea RHEA:86791CC BY 4.0Reference data
cyclic ADP-beta-D-ribose+water1-(5-phospho-beta-D-ribosyl)-5'-AMP+2hydron
Catalysed by ADPRM
Reaction pageDirection not assertedBalanced
Rhea RHEA:86799CC BY 4.0Reference data