propionyl-CoA

Three steps

• psychosineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 1 morecytosol, Golgi apparatus

• glyoxylic acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, peroxisome

• ferrocytochrome cReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of L-lactate and propanoate (cytosol to extracellular)
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space, mitochondrial matrix

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 5 morecytosol, Golgi apparatus, mitochondrial matrix

• oxalic acidReach from here →
  1. Active Transport
  2. Carnitine Transport by Atb0
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC6A14, SLC26A6mitochondrial matrix, cytosol, extracellular space

• a cholesterol esterReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 3 morecytosol, Golgi apparatus

• taurolithocholateReach from here →
  1. Propanoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by ACOT7, BAATcytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• L-isoleucineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• CHEBI:17203Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 17 routes

• propanoyl-4'-phosphopantetheineReach from here →
  1. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
  2. (S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2
  3. propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by PCCA, PCCB, ECHDC1, NUDT19 and 2 moremitochondrial matrix

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. Propanoyl-CoA hydrolase
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  3. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by ACOT7, CRAT, CROT, NUDT19cytosol, peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• itaconateReach from here →
  1. Propanoyl-CoA hydrolase
  2. Itaconate:CoA ligase (GDP-forming)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACOT7, SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 4 routes

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 17alpha-hydroxyprogesteroneReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular space, endoplasmic reticulum

• propanoateReach from here →
  1. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
  2. (S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2
  3. propanoyl-CoA + H2O = propanoate + CoA + H(+)

  Catalysed by PCCA, PCCB, ECHDC1, ACOT8 and 2 moremitochondrial matrix

• aceneuramateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• 5'-deoxyadenosineReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 5 morecytosol, extracellular space

• all-trans-retinolReach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by ACOT7, DGAT1, LRAT, AWAT1 and 2 morecytosolOne of 2 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 5 morecytosol, Golgi apparatus

• AH2Reach from here →
  1. Propanoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by ACOT7, BAAT, MTO1cytosolOne of 6 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Lecithin Retinol Acyltransferase (11-Cis)

  Catalysed by ACOT7, DGAT1, LRAT, AWAT1 and 2 morecytosol

• S-methyl-5'-thioadenosineReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

  Catalysed by ACOT7, SAT1, SAT2, SRM and 1 morecytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• hexadecanalReach from here →
  1. Active Transport
  2. Utilized Transport
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by ALDH3B1, ALDH3B2, ALDH3A2mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by ACOT7, DGAT1, LRAT, AWAT1 and 3 morecytosol

• Ala-tRNA(Ala)Reach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ACOT7, AARS1cytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. Active Transport
  2. Carnitine Transport by Atb0
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC6A14, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• 4-methylumbelliferyl acetateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 4 morecytosol, extracellular space

• CHEBI:17769Reach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. spermidine:(acceptor) oxidoreductase

  Catalysed by ACOT7, SAT1, SAT2cytosol

• urateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of L-lactate and propanoate (cytosol to extracellular)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• a 1,2-diacyl-sn-glycerolReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 4 morecytosol, Golgi apparatus

• a triacylglycerolReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 6 morecytosol, Golgi apparatus

• CHEBI:17895Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 21 routes

• all-trans-retinalReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A8cytosol, extracellular space

• butanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by ACOT7, ACSM4, ACSM1, ACSM2A and 9 morecytosol

• CHEBI:18019Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 11 routes

• 4-fumarylacetoacetateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetoacetate and propanoate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• L-glutamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 30 routes

• dTDPReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 5 morecytosol, extracellular space

• spermine monoaldehydeReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermine)
  3. primary-amine oxidase (spermine)

  Catalysed by ACOT7, SAT1, SAT2, AOC2 and 2 morecytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of Hydroxy-Proline

  Catalysed by ACOT7, SLC1A4cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• CHEBI:18132Reach from here →
  1. Propanoyl-CoA hydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP:choline phosphotransferase

  Catalysed by ACOT7, CHAT, CHKA, CHKBcytosol, nucleus

• N-carbamoyl-beta-alanineReach from here →
  1. Active Transport
  2. Carnitine Transport by Atb0
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• dodecanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. Lauroyl-CoA hydrolase

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 8 morecytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• N-(4-aminobutyl)-3-aminopropanalReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. primary-amine oxidase (spermidine)

  Catalysed by ACOT7, SAT1, SAT2, AOC2 and 2 morecytosolOne of 3 routes