CHEBI:1307929

Two steps

• CHEBI:17312Reach from here →
  1. Sterol O-Acyltransferase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SOAT2, SOAT1endoplasmic reticulum, cytosolOne of 2 routes

• linoleic acidReach from here →
  1. Acyl-CoA:cholesterol O-acyltransferase
  2. Steryl-ester acylhydrolase

  Catalysed by SOAT2, SOAT1, CEL, LIPAendoplasmic reticulum, lysosomeOne of 2 routes

• L-cysteineReach from here →
  1. Sterol O-Acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SOAT2, SOAT1, NAGSendoplasmic reticulum, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SOAT2, SOAT1, HADHA, ACADVL and 1 moreendoplasmic reticulum, mitochondrial matrix

• 7alpha-hydroxycholest-4-en-3-oneReach from here →
  1. cytochrome P450 (cholesterol)
  2. 7alpha-Hydroxycholesterol:NAD+ 3-oxidoreductase

  Catalysed by CYP7A1, HSD3B7endoplasmic reticulumOne of 5 routes

• CHEBI:17927Reach from here →
  1. Sterol O-Acyltransferase
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SOAT2, SOAT1endoplasmic reticulum, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SOAT2, SOAT1, HADHA, ACAA2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SOAT2, SOAT1, HADHA, ACADVL and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SOAT2, SOAT1, HADHA, ACADVL and 1 moreendoplasmic reticulum, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SOAT2, SOAT1, ECHS1, ACAA2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SOAT2, SOAT1, ECHS1, ACAA2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• octadecanoateReach from here →
  1. Acyl-CoA:cholesterol O-acyltransferase
  2. Steryl-ester acylhydrolase

  Catalysed by SOAT2, SOAT1, CEL, LIPAendoplasmic reticulum, lysosomeOne of 2 routes

• CHEBI:27540Reach from here →
  1. Sterol O-Acyltransferase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SOAT2, SOAT1, ACSM4, ACSM1 and 4 moreendoplasmic reticulum, cytosolOne of 6 routes

• 7-dehydrodesmosterolReach from here →
  1. 3-hydroxyacyl-CoA dehydrogenase (desmosterol)
  2. 7-Dehydrocholesterol Reductase

  Catalysed by DHCR7nucleus

• elaidic acidReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. Sterol O-Acyltransferase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SOAT2, SOAT1, ACAA1, SCP2 and 1 moreendoplasmic reticulum, peroxisomeOne of 7 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. cytochrome P450 (cholesterol)
  2. cytochrome P450 (pregnenolone)

  Catalysed by CYP11A1, CYP17A1mitochondrial matrix, cytosolOne of 3 routes

• a fatty acidReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 1 morecytosol

• (9Z)-octadecenoateReach from here →
  1. Acyl-CoA:cholesterol O-acyltransferase
  2. Steryl-ester acylhydrolase

  Catalysed by SOAT2, SOAT1, CEL, LIPAendoplasmic reticulum, lysosomeOne of 3 routes

• fatty acidReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase

  Catalysed by LCAT, LYPLA1, LYPLA2, PLA2G4A and 7 morecytosol

• 7alpha,25-dihydroxycholesterolReach from here →
  1. cholesterol 25-hydroxylase (cholesterol)
  2. cytochrome P450 (25-hydroxycholesterol)

  Catalysed by CH25H, CYP7B1endoplasmic reticulumOne of 2 routes

• (24S)-7alpha-dihydroxycholesterolReach from here →
  1. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  2. Oxysterol 7-Alpha-Hydroxylase

  Catalysed by CYP46A1, CYP39A1endoplasmic reticulumOne of 4 routes

• taurineReach from here →
  1. Sterol O-Acyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SOAT2, SOAT1, BAATendoplasmic reticulum, cytosolOne of 2 routes

• glycineReach from here →
  1. Sterol O-Acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by SOAT2, SOAT1, GLYAT, GLYATL2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SOAT2, SOAT1, ALDH6A1endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SOAT2, SOAT1endoplasmic reticulum, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SOAT2, SOAT1, ACP2endoplasmic reticulum, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by SOAT2, SOAT1endoplasmic reticulum, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SOAT2, SOAT1, ACAA1, MYO5Bendoplasmic reticulum, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SOAT2, SOAT1, ACSM4, ACSM1 and 4 moreendoplasmic reticulum, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Production of Glutaryl Carnitine

  Catalysed by SOAT2, SOAT1, CPT1A, CPT1C and 1 moreendoplasmic reticulum, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SOAT2, SOAT1, SUCLG1, SUCLG2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SOAT2, SOAT1, CROTendoplasmic reticulum, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. phytanate-CoA ligase

  Catalysed by SOAT2, SOAT1endoplasmic reticulum, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SOAT2, SOAT1, SLC27A2, ACSL4 and 5 moreendoplasmic reticulum, cytosolOne of 15 routes

• sphing-4-enineReach from here →
  1. Sterol O-Acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SOAT2, SOAT1, ASAH1, ACER2 and 2 moreendoplasmic reticulum, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Sterol O-Acyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SOAT2, SOAT1, SAT1, SAT2endoplasmic reticulum, cytosolOne of 3 routes

• L-methionineReach from here →
  1. Sterol O-Acyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by SOAT2, SOAT1, NAGSendoplasmic reticulum, mitochondrial matrix

• L-alanineReach from here →
  1. Sterol O-Acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by SOAT2, SOAT1endoplasmic reticulum, mitochondrial matrix

• L-asparagineReach from here →
  1. Sterol O-Acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by SOAT2, SOAT1, NAGSendoplasmic reticulum, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Sterol O-Acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by SOAT2, SOAT1, NAGSendoplasmic reticulum, mitochondrial matrix

• an acyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SOAT2, SOAT1, ASAH1, ACER2 and 2 moreendoplasmic reticulum, Golgi apparatusOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Sterol O-Acyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by SOAT2, SOAT1, HADHA, ACAA2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 3 routes