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Proteins/UNIPROT:Q05D32
Serine/threonine phosphatase that promotes gluconeogenesis by dephosphorylating FOXO1 and FOXO3A, promoting their nuclear retention and enhancing their transcriptional activity on PCK1 and G6PC1, key enzymes in hepatic gluconeogenesis. Essential for proper embryonic skeletal development by regulating chondrocyte survival through dephosphorylation of FOXO3 (By similarity). By maintaining FOXO3 in its active, dephosphorylated form, inhibits excessive apoptosis of chondrocytes, which is essential for normal endochondral ossification and cartilage formation (By similarity)..
Function from UniProtKB (Q05D32), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 statements
2 statements · 2 reference databases · Subject: CTDSPL2 · Sources: Hetionet, Human-GEM
6 reactions
MAM00555c+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Catalysed by MTMR7 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or SGPP1 or CTDSPL2 or PTPRQ or MTMR6 or DUSP11 and 8 more alternatives
Reaction pageLeft to right
4 names
Resolves to: CTDSPL2
Human-GEM MAR06545CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+water1-phosphatidyl-1D-myo-inositol+phosphate(3-)
Catalysed by MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or PMPCA or INPP5F and 1 more alternative
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-GO:0005829
Human-GEM MAR06547CC BY 4.0Reference data
water+MAM02734cMAM00551c+phosphate(3-)
Catalysed by MTMR7 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or INPP5F or ASB12 and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-GO:0005829
Human-GEM MAR06557CC BY 4.0Reference data
water+MAM02735ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+phosphate(3-)
Catalysed by MTMR7 or PHPT1 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or NT5C or CTDSPL2 or PTPRQ or MTMR6 and 8 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-GO:0005829
Human-GEM MAR06591CC BY 4.0Reference data
O-phospho-L-seryl-[protein]+waterL-seryl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 61 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20629CC BY 4.0Reference data
O-phospho-L-threonyl-[protein]+waterL-threonyl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 59 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47004CC BY 4.0Reference data