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Proteins/UNIPROT:P00568
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity)..
Function from UniProtKB (P00568), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
161 statements
161 statements · 7 reference databases · Subject: AK1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
19 reactions
5 names
Resolves to: AK1
Reaction pageReversibleBalancedEC 2.7.4.3mitochondrial matrix
Human-GEM MAR04004CC BY 4.0Reference data
ADP+CHEBI:16174ATP+MAM01639c
Catalysed by AK2 or AK6 or AK1 or AK7 or AK3 or AK5 or AK9 or AK4 or AK8 or ACAD9
Reaction pageReversibleBalancedEC 2.7.4.11, 2.7.4.3cytosol
Human-GEM MAR04480CC BY 4.0Reference data
Catalysed by AK1 or AK4 or AK2 or AK9 or AK7 or AK8 or AK6 or AK5
Reaction pageDirection not assertedBalanced
Rhea RHEA:12973CC BY 4.0Reference data
a ribonucleoside 5'-diphosphate+ATP(4-)a ribonucleoside 5'-triphosphate+ADP(3-)
Catalysed by NME4 or NME6 or AK1 or NME1 or NME2 or AK4 or CMPK1 or NME3 or CMPK2 or AK9 or AK7 or AK8 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18113CC BY 4.0Reference data
CHEBI:58245+ATP(4-)dADP+ADP(3-)
Catalysed by AK1 or AK4 or AK9
Reaction pageDirection not assertedBalanced
Rhea RHEA:23100CC BY 4.0Reference data
CHEBI:58043+ATP(4-)a ribonucleoside 5'-diphosphate+ADP(3-)
Catalysed by AK1 or AK4 or AK9
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24036CC BY 4.0Reference data
Catalysed by NME4 or NME6 or AK1 or NME1 or NME2 or AK4 or NME3 or AK9
Reaction pageLeft to rightBalanced
Rhea RHEA:25098CC BY 4.0Reference data
Catalysed by NME4 or AK1 or NME1 or NME2 or AK4 or NME3 or AK9
Reaction pageLeft to rightBalanced
Rhea RHEA:27686CC BY 4.0Reference data
Catalysed by NME4 or AK1 or AK4 or AK9
Reaction pageLeft to rightBalanced
Rhea RHEA:27690CC BY 4.0Reference data
CHEBI:73316+ATP(4-)CHEBI:61560+ADP(3-)
Catalysed by NME4 or NME6 or AK1 or NME1 or NME2 or AK4 or CMPK1 or NME3 or CMPK2 or AK7 or AK8 or AK5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44640CC BY 4.0Reference data
thiamine diphosphate+ADP(3-)thiamine triphosphate+AMP
Catalysed by AK1
Reaction pageDirection not assertedBalanced
Rhea RHEA:69180CC BY 4.0Reference data