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Proteins/UNIPROT:Q14376
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids..
Function from UniProtKB (Q14376), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
456 statements
456 statements · 7 reference databases · Subject: GALE · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
5 reactions
CHEBI:67119MAM03108c
Catalysed by GALE
Reaction pageReversibleBalancedEC 5.1.3.2cytosol
Human-GEM MAR04128CC BY 4.0Reference data
MAM03110cCHEBI:16264
Catalysed by GALE
Reaction pageReversibleBalancedEC 5.1.3.7cytosol
Human-GEM MAR04159CC BY 4.0Reference data
MAM01750cMAM01751c
Catalysed by GALE
6 names
Resolves to: GALE
Human-GEM MAR07698CC BY 4.0Reference data
UDP-N-acetyl-alpha-D-glucosamineUDP-N-acetyl-alpha-D-galactosamine
Catalysed by GALE
Reaction pageDirection not assertedBalanced
Rhea RHEA:20517CC BY 4.0Reference data
UDP-alpha-D-glucoseUDP-alpha-D-galactose
Catalysed by GALE
Reaction pageDirection not assertedBalanced
Rhea RHEA:22168CC BY 4.0Reference data