Loading the page.
Proteins/UNIPROT:P29460
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC..
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis..
Function from UniProtKB (P29460), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
83 statements
83 statements · 4 reference databases · Subject: IL12B · Sources: gene ontology, Hetionet, Reactome, WikiPathways
6 names
Resolves to: IL12B