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Proteins/UNIPROT:Q2M2I8
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity..
(Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue..
Function from UniProtKB (Q2M2I8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
24 statements
24 statements · 3 reference databases · Subject: AAK1 · Sources: gene ontology, Hetionet, Reactome
2 reactions
2 names
Resolves to: AAK1
Rhea RHEA:17989CC BY 4.0Reference data