Proteins/UNIPROT:Q13614

MTMR2

ProteinUNIPROT:Q13614Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation..

Function from UniProtKB (Q13614), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

Charcot-Marie-Tooth disease type 4B1 has a germline basis in MTMR2DiseaseGenCC HGNC:7450|MONDO:0011066Inferred only
demyelinating hereditary motor and sensory neuropathy has a germline basis in MTMR2DiseaseGenCC HGNC:7450|MONDO:0018776Inferred only

Statements

30 statements

30 statements · 7 reference databases · Subject: MTMR2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Order

MUC19 covaries with MTMR2ProteinHetionet hetionet:covaries:283463-8898Inferred only
TIGD2 covaries with MTMR2ProteinHetionet hetionet:covaries:166815-8898Inferred only
MTMR2 is expressed in male germ cellCell typeBgee ENSG00000087053Inferred only
MTMR2 is expressed in parotid glandAnatomyBgee ENSG00000087053Inferred only
MTMR2 is expressed in spermCell typeBgee ENSG00000087053Inferred only
MTMR2 interacts with MTMR12ProteinHetionet hetionet:interacts:54545-8898Inferred only
NEFL interacts with MTMR2ProteinHetionet hetionet:interacts:4747-8898Inferred only
SBF1 interacts with MTMR2ProteinHetionet hetionet:interacts:6305-8898Inferred only
SNTA1 interacts with MTMR2ProteinHetionet hetionet:interacts:6640-8898Inferred only
UBC interacts with MTMR2ProteinHetionet hetionet:interacts:7316-8898Inferred only
MTMR2 participates in Intracellular trafficking proteins involved in CMT neuropathyPathwayWikiPathways WP4856Inferred only
MTMR2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only

Show the remaining 18

MTMR2 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
MTMR2 participates in Phosphatidyl inositol phosphate pathwayPathwayWikiPathways WP5411Inferred only
MTMR2 participates in Phosphoinositides metabolismPathwayWikiPathways WP4971Inferred only
MTMR2 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
MTMR2 participates in PI MetabolismPathwayReactome R-HSA-1483255Inferred only
MTMR2 participates in Synthesis of PIPs at the early endosome membranePathwayReactome R-HSA-1660516Inferred only
MTMR2 participates in Synthesis of PIPs at the ER membranePathwayReactome R-HSA-1483248Inferred only
MTMR2 participates in Synthesis of PIPs at the late endosome membranePathwayReactome R-HSA-1660517Inferred only
MTMR2 participates in Synthesis of PIPs at the plasma membranePathwayReactome R-HSA-1660499Inferred only
MTMR2 regulates negative regulation of endocytosisBiological processgene ontology Q13614|GO:0045806Inferred only
MTMR2 regulates negative regulation of excitatory postsynaptic potentialBiological processgene ontology Q13614|GO:0090394Inferred only
MTMR2 regulates negative regulation of receptor catabolic processBiological processgene ontology Q13614|GO:2000645Inferred only
MTMR2 regulates negative regulation of receptor internalizationBiological processgene ontology Q13614|GO:0002091Inferred only
MTMR2 regulates positive regulation of early endosome to late endosome transportBiological processgene ontology Q13614|GO:2000643Inferred only
MTMR2 regulates regulation of phosphatidylinositol dephosphorylationBiological processgene ontology Q13614|GO:0060304Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) is a substrate of MTMR2CompoundHuman-GEM MAR06547Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) is a substrate of MTMR2CompoundRhea RHEA:12316Inferred only
FAD is transported by MTMR2CompoundHuman-GEM MAR06512Inferred only

Reactions

9 reactions

FADFAD
Transported by MTREX or PHPT1 or MTMR2 or PLPP3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06512CC BY 4.0Reference data
MAM00555c+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Catalysed by MTMR7 or MTMR1 or MTMR2

Other names

3 names

Resolves to: MTMR2

Also called: KIAA1073Myotubularin-related protein 2Phosphatidylinositol-3-phosphate phosphatase

← Every protein Find it in the graph →

or

MTMR8

or TNS2

or NT5DC3

or FIG4

or SGPP1

or CTDSPL2

or PTPRQ

or MTMR6

or DUSP11

and 8 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol

Human-GEM MAR06545CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+water1-phosphatidyl-1D-myo-inositol+phosphate(3-)

Catalysed by MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or PMPCA or INPP5F and 1 more alternative

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol

Human-GEM MAR06547CC BY 4.0Reference data

water+MAM02734cMAM00551c+phosphate(3-)

Catalysed by MTMR7 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or INPP5F or ASB12 and 3 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol

Human-GEM MAR06557CC BY 4.0Reference data

water+MAM02735ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+phosphate(3-)

Catalysed by MTMR7 or PHPT1 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or NT5C or CTDSPL2 or PTPRQ or MTMR6 and 8 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol

Human-GEM MAR06591CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+hydrogenphosphate

Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or SACM1L or MTMR4 or MTMR7 or MTMR6

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:12316CC BY 4.0Reference data

CHEBI:57923+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+hydrogenphosphate

Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or MTMR4 or MTMR6

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:39019CC BY 4.0Reference data

CHEBI:78934+waterCHEBI:65221+hydrogenphosphate

Catalysed by MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR4 or MTMR6

Reaction pageLeft to rightBalanced

Rhea RHEA:42328CC BY 4.0Reference data

CHEBI:85342+waterCHEBI:78911+hydrogenphosphate

Catalysed by MTM1 or MTMR2 or MTMR8 or MTMR4 or MTMR6

Reaction pageLeft to rightBalanced

Rhea RHEA:45632CC BY 4.0Reference data