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Proteins/UNIPROT:Q96EQ8
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation..
Function from UniProtKB (Q96EQ8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
213 statements
213 statements · 4 reference databases · Subject: RNF125 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 reaction
3 names
Resolves to: RNF125
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data