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Proteins/UNIPROT:Q9UNP9
Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity..
Function from UniProtKB (Q9UNP9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
294 statements
294 statements · 4 reference databases · Subject: PPIE · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
5 names
Resolves to: PPIE
[protein]-peptidylproline (omega=180)[protein]-peptidylproline (omega=0)
Catalysed by PPIH or FKBP9 or PPIB or FKBP2 or PPIF or NKTR or PPIC or PPIA or FKBP1A or FKBP1B or FKBP3 or FKBP4 and 16 more alternatives
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16237CC BY 4.0Reference data