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Proteins/UNIPROT:Q15046
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity..
(Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation..
Function from UniProtKB (Q15046), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
357 statements
357 statements · 8 reference databases · Subject: KARS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
2 reactions
ATP+CHEBI:18019+MAM03074cAMP+MAM02405c+diphosphate(3-)
Catalysed by KARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.6cytosol
Human-GEM MAR05142CC BY 4.0Reference data
CHEBI:78442+L-lysine+ATP(4-)CHEBI:78529+AMP+diphosphate(3-)
Catalysed by
4 names
Resolves to: KARS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:20792CC BY 4.0Reference data