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Proteins/UNIPROT:Q9Y217
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels..
Function from UniProtKB (Q9Y217), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 6 reference databases · Subject: MTMR6 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
MAM00555c+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Catalysed by MTMR7 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or SGPP1 or CTDSPL2 or PTPRQ or MTMR6 or DUSP11 and 8 more alternatives
Reaction pageLeft to right
2 names
Resolves to: MTMR6
Human-GEM MAR06545CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+water1-phosphatidyl-1D-myo-inositol+phosphate(3-)
Catalysed by MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or PMPCA or INPP5F and 1 more alternative
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol
Human-GEM MAR06547CC BY 4.0Reference data
water+MAM02734cMAM00551c+phosphate(3-)
Catalysed by MTMR7 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or INPP5F or ASB12 and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol
Human-GEM MAR06557CC BY 4.0Reference data
water+MAM02735ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+phosphate(3-)
Catalysed by MTMR7 or PHPT1 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or NT5C or CTDSPL2 or PTPRQ or MTMR6 and 8 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol
Human-GEM MAR06591CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or SACM1L or MTMR4 or MTMR7 or MTMR6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12316CC BY 4.0Reference data
CHEBI:57923+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or MTMR4 or MTMR6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39019CC BY 4.0Reference data
CHEBI:78934+waterCHEBI:65221+hydrogenphosphate
Catalysed by MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR4 or MTMR6
Reaction pageLeft to rightBalanced
Rhea RHEA:42328CC BY 4.0Reference data
CHEBI:85342+waterCHEBI:78911+hydrogenphosphate
Catalysed by MTM1 or MTMR2 or MTMR8 or MTMR4 or MTMR6
Reaction pageLeft to rightBalanced
Rhea RHEA:45632CC BY 4.0Reference data