Proteins/UNIPROT:Q92562

FIG4

ProteinUNIPROT:Q92562

Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro..

Function from UniProtKB (Q92562), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

6 rows

amyotrophic lateral sclerosis has a germline basis in FIG4DiseaseGenCC HGNC:16873|MONDO:0004976Inferred only
amyotrophic lateral sclerosis type 11 has a germline basis in FIG4DiseaseGenCC HGNC:16873|MONDO:0012945Inferred only
bilateral parasagittal parieto-occipital polymicrogyria has a germline basis in FIG4DiseaseGenCC HGNC:16873|MONDO:0012986Inferred only
Charcot-Marie-Tooth disease has a germline basis in FIG4DiseaseGenCC HGNC:16873|MONDO:0015626Inferred only
Charcot-Marie-Tooth disease type 4J has a germline basis in FIG4DiseaseGenCC HGNC:16873|MONDO:0012640Inferred only
Yunis-Varon syndrome has a germline basis in FIG4DiseaseGenCC HGNC:16873|MONDO:0008995Inferred only

Statements

14 statements

14 statements · 6 reference databases · Subject: FIG4 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Order

UBC interacts with FIG4ProteinHetionet hetionet:interacts:7316-9896Inferred only
FIG4 interacts with VAC14ProteinHetionet hetionet:interacts:55697-9896Inferred only
FIG4 participates in Intracellular trafficking proteins involved in CMT neuropathyPathwayWikiPathways WP4856Inferred only
FIG4 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
FIG4 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
FIG4 participates in Phosphatidyl inositol phosphate pathwayPathwayWikiPathways WP5411Inferred only
FIG4 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
FIG4 participates in PI MetabolismPathwayReactome R-HSA-1483255Inferred only
FIG4 participates in Synthesis of PIPs at the early endosome membranePathwayReactome R-HSA-1660516Inferred only
FIG4 participates in Synthesis of PIPs at the Golgi membranePathwayReactome R-HSA-1660514Inferred only
FIG4 participates in Synthesis of PIPs at the late endosome membranePathwayReactome R-HSA-1660517Inferred only
FIG4 regulates positive regulation of neuron projection developmentBiological processgene ontology Q92562|GO:0010976Inferred only

Show the remaining 2

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) is a substrate of FIG4CompoundHuman-GEM MAR06547Inferred only
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of FIG4CompoundRhea RHEA:22764Inferred only

Reactions

8 reactions

MAM00555c+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Catalysed by MTMR7 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or SGPP1 or CTDSPL2 or PTPRQ or MTMR6 or DUSP11 and 8 more alternatives
Reaction pageLeft to right

Other names

5 names

Resolves to: FIG4

Also called: KIAA0274Phosphatidylinositol 3,5-bisphosphate 5-phosphataseSAC domain-containing protein 3SAC3Serine-protein phosphatase FIG4

← Every protein Find it in the graph →

Balance undeterminable

EC 3.1.3.-

cytosol

Human-GEM MAR06545CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+water1-phosphatidyl-1D-myo-inositol+phosphate(3-)

Catalysed by MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or PMPCA or INPP5F and 1 more alternative

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol

Human-GEM MAR06547CC BY 4.0Reference data

water+MAM02734cMAM00551c+phosphate(3-)

Catalysed by MTMR7 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or INPP5F or ASB12 and 3 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol

Human-GEM MAR06557CC BY 4.0Reference data

water+MAM02735ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+phosphate(3-)

Catalysed by MTMR7 or PHPT1 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or NT5C or CTDSPL2 or PTPRQ or MTMR6 and 8 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol

Human-GEM MAR06591CC BY 4.0Reference data

O-phospho-L-seryl-[protein]+waterL-seryl-[protein]+hydrogenphosphate

Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 61 more alternatives

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:20629CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+hydrogenphosphate

Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5J or FIG4 or INPP5D or INPP5K or INPP5E

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:22764CC BY 4.0Reference data

CHEBI:57836+waterCHEBI:57658+hydrogenphosphate

Catalysed by SYNJ2 or INPPL1 or SYNJ1 or OCRL or FIG4 or INPP5D or INPP5K or INPP5E

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:25528CC BY 4.0Reference data

CHEBI:57923+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+hydrogenphosphate

Catalysed by FIG4 or INPP5E

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:32955CC BY 4.0Reference data