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Proteins/UNIPROT:P07992
[Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4..
[Isoform 2]: Not functional in the nucleotide excision repair pathway..
[Isoform 3]: Not functional in the nucleotide excision repair pathway..
[Isoform 4]: Not functional in the nucleotide excision repair pathway..
Function from UniProtKB (P07992), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
187 statements
187 statements · 4 reference databases · Subject: ERCC1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 name
Resolves to: ERCC1