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Proteins/UNIPROT:Q13496
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels..
Function from UniProtKB (Q13496), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
22 statements
22 statements · 6 reference databases · Subject: MTM1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+water1-phosphatidyl-1D-myo-inositol+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.64cytosol
Human-GEM MAR06543CC BY 4.0Reference data
water+MAM02172c1D-myo-inositol 1-phosphate+phosphate(3-)
Catalysed by MTM1
3 names
Resolves to: MTM1
Human-GEM MAR08802CC BY 4.0Reference data
MAM00551n+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+phosphate(3-)
Catalysed by MTM1
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.64nucleus
Human-GEM MAR08809CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+water1-phosphatidyl-1D-myo-inositol+phosphate(3-)
Catalysed by MTM1
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.64, 3.1.3.67nucleus
Human-GEM MAR08812CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or SACM1L or MTMR4 or MTMR7 or MTMR6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12316CC BY 4.0Reference data
CHEBI:57923+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or MTMR4 or MTMR6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39019CC BY 4.0Reference data
CHEBI:78934+waterCHEBI:65221+hydrogenphosphate
Catalysed by MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR4 or MTMR6
Reaction pageLeft to rightBalanced
Rhea RHEA:42328CC BY 4.0Reference data
CHEBI:85342+waterCHEBI:78911+hydrogenphosphate
Catalysed by MTM1 or MTMR2 or MTMR8 or MTMR4 or MTMR6
Reaction pageLeft to rightBalanced
Rhea RHEA:45632CC BY 4.0Reference data
CHEBI:78994+waterCHEBI:84968+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:45636CC BY 4.0Reference data