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Proteins/UNIPROT:O60318
[Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations..
[Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations..
Function from UniProtKB (O60318), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
55 statements
55 statements · 4 reference databases · Subject: MCM3AP · Sources: Bgee, gene ontology, Hetionet, Reactome
1 reaction
L-lysyl-[histone]+acetyl-CoAN(6)-acetyl-L-lysyl-[histone]+coenzyme A(4-)+hydron
Catalysed by MCM3AP or KAT7 or EP300 or CREBBP or KAT2A or KAT2B or KAT5 or KAT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21992CC BY 4.0Reference data
6 names
Resolves to: MCM3AP