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Proteins/UNIPROT:O00442
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury..
Function from UniProtKB (O00442), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
154 statements
154 statements · 3 reference databases · Subject: RTCA · Sources: Bgee, gene ontology, Hetionet
2 reactions
ATP+MAM02848cAMP+diphosphate(3-)+MAM02849c
Catalysed by RTCA
Reaction pageLeft to rightBalance undeterminableEC 6.5.1.4cytosol
Human-GEM MAR09546CC BY 4.0Reference data
a 3'-end 3'-phospho-ribonucleotide-RNA+ATP(4-)a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA+AMP+diphosphate(3-)
Catalysed by RTCA
Reaction pageDirection not asserted
8 names
Resolves to: RTCA
Rhea RHEA:23976CC BY 4.0Reference data