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Proteins/UNIPROT:Q9UBF8
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). May play an important role in the inner ear development..
(Microbial infection) Plays an essential role in Aichi virus RNA replication. Recruited by ACBD3 at the viral replication sites..
(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV..
Function from UniProtKB (Q9UBF8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
67 statements
67 statements · 7 reference databases · Subject: PI4KB · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATPADP+proton+MAM02736g
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.67Golgi apparatus
Human-GEM MAR03300CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATPADP+proton+MAM02736m
Catalysed by
7 names
Resolves to: PI4KB
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.67mitochondrial matrix
Human-GEM MAR03303CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATPADP+proton+MAM02736r
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.137endoplasmic reticulum
Human-GEM MAR03308CC BY 4.0Reference data
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ADP+proton
Catalysed by PI4K2B or PI4KB or PI4K2A or PI4KA
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.67cytosol
Human-GEM MAR06546CC BY 4.0Reference data
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ADP+proton
Catalysed by PI4K2B or PI4KB or PI4K2A or PI4KA
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.67nucleus
Human-GEM MAR08830CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+ATP(4-)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ADP(3-)+hydron
Catalysed by PI4KA or PI4K2B or PI4K2A or PI4KB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19877CC BY 4.0Reference data