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Proteins/UNIPROT:Q07864
Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair. Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation..
Function from UniProtKB (Q07864), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 rows
72 statements
72 statements · 4 reference databases · Subject: POLE · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
2 reactions
3 names
Resolves to: POLE
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data
DNA(n)+CHEBI:61560DNA(n+1)+diphosphate(3-)
Catalysed by TERT or REV3L or POLQ or DNTT or POLB or POLA1 or POLD1 or POLG or POLE or POLN or POLM or POLK and 3 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22508CC BY 4.0Reference data