Pathway
POLB-Dependent Long Patch Base Excision Repair
During POLB-dependent long patch base excision repair (BER), PARP1 and/or PARP2 is recruited to the BER site along with flap endonuclease FEN1. PARP1 and/or PARP2 and FEN1 facilitate POLB-mediated strand displacement synthesis which involves incorporation of 2-10 nucleotides at the 3' end of the APEX1-created single strand break (SSB). After the DNA strand displacement synthesis is completed and the displaced strand is cleaved, POLB recruits DNA ligase I (LIG1) to ligate the SSB.
REACT:R-HSA-110362Reactome
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: POLB-Dependent Long Patch Base Excision Repair · Sources: Reactome
- ADPRS participates in POLB-Dependent Long Patch Base Excision RepairProteinReactome R-HSA-110362Inferred only
- APEX1 participates in POLB-Dependent Long Patch Base Excision RepairProteinReactome R-HSA-110362Inferred only
- FEN1 participates in POLB-Dependent Long Patch Base Excision RepairProteinReactome R-HSA-110362Inferred only
- LIG1 participates in POLB-Dependent Long Patch Base Excision RepairProteinReactome R-HSA-110362Inferred only
- PARG participates in POLB-Dependent Long Patch Base Excision RepairProteinReactome R-HSA-110362Inferred only
- PARP1 participates in POLB-Dependent Long Patch Base Excision RepairProteinReactome R-HSA-110362Inferred only
- PARP2 participates in POLB-Dependent Long Patch Base Excision RepairProteinReactome R-HSA-110362Inferred only
- POLB participates in POLB-Dependent Long Patch Base Excision RepairProteinReactome R-HSA-110362Inferred only