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Proteins/UNIPROT:Q96T60
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone..
Function from UniProtKB (Q96T60), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
385 statements
385 statements · 4 reference databases · Subject: PNKP · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
3 reactions
MAM00915c+waterphosphate(3-)+MAM02755c
Catalysed by PNKP
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.32cytosol
Human-GEM MAR09506CC BY 4.0Reference data
a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA+watera 3'-end 2'-deoxyribonucleotide-DNA+hydrogenphosphate
Catalysed by PNKP
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:14113CC BY 4.0Reference data
4 names
Resolves to: PNKP
a 5'-end dephospho-2'-deoxyribonucleoside-DNA+ATP(4-)a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+ADP(3-)+hydron
Catalysed by NOL9 or CLP1 or PNKP
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15669CC BY 4.0Reference data