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Proteins/UNIPROT:Q15084
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin..
Function from UniProtKB (Q15084), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
46 statements
46 statements · 4 reference databases · Subject: PDIA6 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
1 reaction
2CHEBI:16856+MAM03169cglutathione disulfide+MAM03170c
Catalysed by PDIA5 or PDIA6 or PDIA4 or TMX3 or PDIA3 or P4HB
Reaction pageLeft to rightBalancedEC 5.3.4.1cytosol
Human-GEM MAR09806CC BY 4.0Reference data
8 names
Resolves to: PDIA6