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Proteins/UNIPROT:Q9UNA4
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity..
Function from UniProtKB (Q9UNA4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
38 statements
38 statements · 5 reference databases · Subject: POLI · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
2 reactions
3 names
Resolves to: POLI
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data
DNA(n)+CHEBI:61560DNA(n+1)+diphosphate(3-)
Catalysed by TERT or REV3L or POLQ or DNTT or POLB or POLA1 or POLD1 or POLG or POLE or POLN or POLM or POLK and 3 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22508CC BY 4.0Reference data