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Proteins/UNIPROT:O15527
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Function from UniProtKB (O15527), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
166 statements
166 statements · 4 reference databases · Subject: OGG1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 reaction
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNAa 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA+a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+hydron
Catalysed by OGG1 or POLB or XRCC6 or XRCC5 or RPS3 or NTHL1 or ALKBH1 or NEIL3 or NEIL2 or NEIL1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:66592CC BY 4.0Reference data
6 names
Resolves to: OGG1