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Proteins/UNIPROT:Q92585
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions..
Function from UniProtKB (Q92585), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
78 statements
78 statements · 4 reference databases · Subject: MAML1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 names
Resolves to: MAML1