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Proteins/UNIPROT:Q9UBT6
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity..
Function from UniProtKB (Q9UBT6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
48 statements
48 statements · 5 reference databases · Subject: POLK · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
2 reactions
3 names
Resolves to: POLK
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data
DNA(n)+CHEBI:61560DNA(n+1)+diphosphate(3-)
Catalysed by TERT or REV3L or POLQ or DNTT or POLB or POLA1 or POLD1 or POLG or POLE or POLN or POLM or POLK and 3 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22508CC BY 4.0Reference data