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Proteins/UNIPROT:P08572
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Function from UniProtKB (P08572), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
107 statements
107 statements · 4 reference databases · Subject: COL4A2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 names
Resolves to: COL4A2