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Proteins/UNIPROT:P78549
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption..
Function from UniProtKB (P78549), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
28 statements
28 statements · 4 reference databases · Subject: NTHL1 · Sources: Hetionet, Reactome, UniProt, WikiPathways
1 reaction
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNAa 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA+a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+hydron
Catalysed by OGG1 or POLB or XRCC6 or XRCC5 or RPS3 or NTHL1 or ALKBH1 or NEIL3 or NEIL2 or NEIL1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:66592CC BY 4.0Reference data
5 names
Resolves to: NTHL1