Proteins/UNIPROT:Q92636

NSMAF

ProteinUNIPROT:Q92636

Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.

Function from UniProtKB (Q92636), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

23 statements

23 statements · 3 reference databases · Subject: NSMAF · Sources: Hetionet, Reactome, WikiPathways

Order

NSMAF covaries with PLPPR3ProteinHetionet hetionet:covaries:79948-8439Inferred only
ACTB interacts with NSMAFProteinHetionet hetionet:interacts:60-8439Inferred only
CD40 interacts with NSMAFProteinHetionet hetionet:interacts:8439-958Inferred only
NSMAF interacts with GABARAPProteinHetionet hetionet:interacts:11337-8439Inferred only
NSMAF interacts with GABARAPL1ProteinHetionet hetionet:interacts:23710-8439Inferred only
NSMAF interacts with GABARAPL2ProteinHetionet hetionet:interacts:11345-8439Inferred only
NSMAF interacts with MAP1LC3BProteinHetionet hetionet:interacts:81631-8439Inferred only
NSMAF interacts with MAP1LC3CProteinHetionet hetionet:interacts:440738-8439Inferred only
NSMAF interacts with RACK1ProteinHetionet hetionet:interacts:10399-8439Inferred only
TNFRSF1A interacts with NSMAFProteinHetionet hetionet:interacts:7132-8439Inferred only
UBC interacts with NSMAFProteinHetionet hetionet:interacts:7316-8439Inferred only
VASP interacts with NSMAFProteinHetionet hetionet:interacts:7408-8439Inferred only

Show the remaining 11

NSMAF participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
NSMAF participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NSMAF participates in TNF alpha signalingPathwayWikiPathways WP231Inferred only
NSMAF participates in TNF signalingPathwayReactome R-HSA-75893Inferred only
NSMAF participates in TNFR1-mediated ceramide productionPathwayReactome R-HSA-5626978Inferred only
ACO2 increases the expression of NSMAFProteinHetionet hetionet:regulates:50-8439Inferred only
E2F5 increases the expression of NSMAFProteinHetionet hetionet:regulates:1875-8439Inferred only
LRSAM1 increases the expression of NSMAFProteinHetionet hetionet:regulates:90678-8439Inferred only
NFE2L2 increases the expression of NSMAFProteinHetionet hetionet:regulates:4780-8439Inferred only
POLB increases the expression of NSMAFProteinHetionet hetionet:regulates:5423-8439Inferred only
ZNF589 increases the expression of NSMAFProteinHetionet hetionet:regulates:51385-8439Inferred only

Other names

3 names

Resolves to: NSMAF

Also called: Factor associated with N-SMase activationFactor associated with neutral sphingomyelinase activationFAN

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