Proteins/UNIPROT:P18887

XRCC1

ProteinUNIPROT:P18887

Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity..

Function from UniProtKB (P18887), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

spinocerebellar ataxia, autosomal recessive 26 has a germline basis in XRCC1DiseaseGenCC HGNC:12828|MONDO:0033116Inferred only

Statements

47 statements

47 statements · 4 reference databases · Subject: XRCC1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

APEX1 interacts with XRCC1ProteinHetionet hetionet:interacts:328-7515Inferred only
XRCC1 interacts with APLFProteinHetionet hetionet:interacts:200558-7515Inferred only
XRCC1 interacts with APTXProteinHetionet hetionet:interacts:54840-7515Inferred only
XRCC1 interacts with ARL6IP5ProteinHetionet hetionet:interacts:10550-7515Inferred only
XRCC1 interacts with CAND1ProteinHetionet hetionet:interacts:55832-7515Inferred only
CSNK2A1 interacts with XRCC1ProteinHetionet hetionet:interacts:1457-7515Inferred only
CSNK2A2 interacts with XRCC1ProteinHetionet hetionet:interacts:1459-7515Inferred only
LIG3 interacts with XRCC1ProteinHetionet hetionet:interacts:3980-7515Inferred only
XRCC1 interacts with NEIL1ProteinHetionet hetionet:interacts:7515-79661Inferred only
OGG1 interacts with XRCC1ProteinHetionet hetionet:interacts:4968-7515Inferred only
PARP1 interacts with XRCC1ProteinHetionet hetionet:interacts:142-7515Inferred only
XRCC1 interacts with PARP2ProteinHetionet hetionet:interacts:10038-7515Inferred only

Show the remaining 35

PCNA interacts with XRCC1ProteinHetionet hetionet:interacts:5111-7515Inferred only
XRCC1 interacts with PNKPProteinHetionet hetionet:interacts:11284-7515Inferred only
POLB interacts with XRCC1ProteinHetionet hetionet:interacts:5423-7515Inferred only
XRCC1 interacts with POLIProteinHetionet hetionet:interacts:11201-7515Inferred only
XRCC1 interacts with RNF146ProteinHetionet hetionet:interacts:7515-81847Inferred only
SUMO1 interacts with XRCC1ProteinHetionet hetionet:interacts:7341-7515Inferred only
SUMO2 interacts with XRCC1ProteinHetionet hetionet:interacts:6613-7515Inferred only
UBC interacts with XRCC1ProteinHetionet hetionet:interacts:7316-7515Inferred only
XPO1 interacts with XRCC1ProteinHetionet hetionet:interacts:7514-7515Inferred only
XRCC1 participates in APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayPathwayReactome R-HSA-5649702Inferred only
XRCC1 participates in Base excision repairPathwayWikiPathways WP4752Inferred only
XRCC1 participates in Base Excision RepairPathwayReactome R-HSA-73884Inferred only
XRCC1 participates in DNA Double-Strand Break RepairPathwayReactome R-HSA-5693532Inferred only
XRCC1 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
XRCC1 participates in Gap-filling DNA repair synthesis and ligation in GG-NERPathwayReactome R-HSA-5696397Inferred only
XRCC1 participates in Gap-filling DNA repair synthesis and ligation in TC-NERPathwayReactome R-HSA-6782210Inferred only
XRCC1 participates in Genes and complexes involved in the DNA repair pathwaysPathwayWikiPathways WP4946Inferred only
XRCC1 participates in Global Genome Nucleotide Excision Repair (GG-NER)PathwayReactome R-HSA-5696399Inferred only
XRCC1 participates in HDR through MMEJ (alt-NHEJ)PathwayReactome R-HSA-5685939Inferred only
XRCC1 participates in Homology Directed RepairPathwayReactome R-HSA-5693538Inferred only
XRCC1 participates in Nucleotide Excision RepairPathwayReactome R-HSA-5696398Inferred only
XRCC1 participates in Nucleotide excision repair in xeroderma pigmentosum PathwayWikiPathways WP5114Inferred only
XRCC1 participates in Resolution of Abasic Sites (AP sites)PathwayReactome R-HSA-73933Inferred only
XRCC1 participates in Resolution of AP sites via the single-nucleotide replacement pathwayPathwayReactome R-HSA-110381Inferred only
XRCC1 participates in Transcription-Coupled Nucleotide Excision Repair (TC-NER)PathwayReactome R-HSA-6781827Inferred only
XRCC1 regulates negative regulation of protection from non-homologous end joining at telomereBiological processgene ontology P18887|GO:1905765Inferred only
XRCC1 regulates negative regulation of protein ADP-ribosylationBiological processgene ontology P18887|GO:0010836Inferred only
XRCC1 regulates regulation of base-excision repairBiological processgene ontology P18887|GO:1905051Inferred only
XRCC1 regulates regulation of DNA repairBiological processgene ontology P18887|GO:0006282Inferred only
ACTB decreases the expression of XRCC1ProteinHetionet hetionet:regulates:60-7515Inferred only
CISH decreases the expression of XRCC1ProteinHetionet hetionet:regulates:1154-7515Inferred only
EIF2AK3 increases the expression of XRCC1ProteinHetionet hetionet:regulates:9451-7515Inferred only
ITGA2 increases the expression of XRCC1ProteinHetionet hetionet:regulates:3673-7515Inferred only
JOSD1 increases the expression of XRCC1ProteinHetionet hetionet:regulates:9929-7515Inferred only
MST1R increases the expression of XRCC1ProteinHetionet hetionet:regulates:4486-7515Inferred only

Other names

2 names

Resolves to: XRCC1

Also called: DNA repair protein XRCC1X-ray repair cross-complementing protein 1

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