Loading the page.
Proteins/UNIPROT:Q9NP87
Catalyzes template-directed nucleotide addition during gap filling at DNA double-strand breaks. Functions as a gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Displays reduced sugar discrimination, incorporating deoxyribonucleotides and ribonucleotides with similar efficiency on DNA primer strands, and is able to polymerize nucleotides on RNA-terminated primer strands in vitro. Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination (By similarity)..
Function from UniProtKB (Q9NP87), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 6 reference databases · Subject: POLM · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
3 names
Resolves to: POLM
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data
DNA(n)+CHEBI:61560DNA(n+1)+diphosphate(3-)
Catalysed by TERT or REV3L or POLQ or DNTT or POLB or POLA1 or POLD1 or POLG or POLE or POLN or POLM or POLK and 3 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22508CC BY 4.0Reference data
DNA(n)+dCTPDNA(n)-C+diphosphate(3-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:86319CC BY 4.0Reference data