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Proteins/UNIPROT:Q9NR33

POLE4

Protein·UNIPROT:Q9NR33

Open in the graph

Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity)..

Function from UniProtKB (Q9NR33), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

50 statements

50 statements · 4 reference databases · Subject: POLE4 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways

Search this listOrder

HSPA13 interacts with POLE4ProteinHetionet hetionet:interacts:56655-6782Inferred only
POLE interacts with POLE4ProteinHetionet hetionet:interacts:5426-56655Inferred only
POLE2 interacts with POLE4ProteinHetionet hetionet:interacts:5427-56655Inferred only
POLE3 interacts with POLE4ProteinHetionet hetionet:interacts:54107-56655Inferred only
UBC interacts with POLE4ProteinHetionet hetionet:interacts:56655-7316Inferred only
UBE3A interacts with POLE4ProteinHetionet hetionet:interacts:56655-7337Inferred only
POLE4 participates in Activation of the pre-replicative complexPathwayReactome R-HSA-68962Inferred only
POLE4 participates in Base excision repairPathwayWikiPathways WP4752Inferred only
POLE4 participates in Base Excision RepairPathwayReactome R-HSA-73884Inferred only
POLE4 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
POLE4 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
POLE4 participates in DNA Damage BypassPathwayReactome R-HSA-73893Inferred only

Show the remaining 38

POLE4 participates in DNA Double-Strand Break RepairPathwayReactome R-HSA-5693532Inferred only
POLE4 participates in DNA mismatch repairPathwayWikiPathways WP531Inferred only
POLE4 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
POLE4 participates in DNA ReplicationPathwayReactome R-HSA-69306Inferred only
POLE4 participates in DNA replication initiationPathwayReactome R-HSA-68952Inferred only
POLE4 participates in DNA Replication Pre-InitiationPathwayReactome R-HSA-69002Inferred only
POLE4 participates in Dual Incision in GG-NERPathwayReactome R-HSA-5696400Inferred only
POLE4 participates in Dual incision in TC-NERPathwayReactome R-HSA-6782135Inferred only
POLE4 participates in G1/S TransitionPathwayReactome R-HSA-69206Inferred only
POLE4 participates in Gap-filling DNA repair synthesis and ligation in GG-NERPathwayReactome R-HSA-5696397Inferred only
POLE4 participates in Gap-filling DNA repair synthesis and ligation in TC-NERPathwayReactome R-HSA-6782210Inferred only
POLE4 participates in Genes and complexes involved in the DNA repair pathwaysPathwayWikiPathways WP4946Inferred only
POLE4 participates in Global Genome Nucleotide Excision Repair (GG-NER)PathwayReactome R-HSA-5696399Inferred only
POLE4 participates in HDR through Homologous Recombination (HRR)PathwayReactome R-HSA-5685942Inferred only
POLE4 participates in HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)PathwayReactome R-HSA-5693567Inferred only
POLE4 participates in Homology Directed RepairPathwayReactome R-HSA-5693538Inferred only
POLE4 participates in miR targeted genes in leukocytesPathwayWikiPathways WP2003Inferred only
POLE4 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
POLE4 participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
POLE4 participates in Mitotic G1 phase and G1/S transitionPathwayReactome R-HSA-453279Inferred only
POLE4 participates in Nucleotide excision repairPathwayWikiPathways WP4753Inferred only
POLE4 participates in Nucleotide Excision RepairPathwayReactome R-HSA-5696398Inferred only
POLE4 participates in Nucleotide excision repair in xeroderma pigmentosum PathwayWikiPathways WP5114Inferred only
POLE4 participates in PCNA-Dependent Long Patch Base Excision RepairPathwayReactome R-HSA-5651801Inferred only
POLE4 participates in Pyrimidine metabolismPathwayWikiPathways WP4022Inferred only
POLE4 participates in Recognition of DNA damage by PCNA-containing replication complexPathwayReactome R-HSA-110314Inferred only
POLE4 participates in Resolution of Abasic Sites (AP sites)PathwayReactome R-HSA-73933Inferred only
POLE4 participates in Resolution of AP sites via the multiple-nucleotide patch replacement pathwayPathwayReactome R-HSA-110373Inferred only
POLE4 participates in S PhasePathwayReactome R-HSA-69242Inferred only
POLE4 participates in Synthesis of DNAPathwayReactome R-HSA-69239Inferred only
POLE4 participates in Termination of translesion DNA synthesisPathwayReactome R-HSA-5656169Inferred only
POLE4 participates in Transcription-Coupled Nucleotide Excision Repair (TC-NER)PathwayReactome R-HSA-6781827Inferred only
POLE4 participates in Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templatePathwayReactome R-HSA-110313Inferred only
POLE4 increases the expression of TSEN2ProteinHetionet hetionet:regulates:56655-80746Inferred only
CHEBI:16284 is a substrate of POLE4CompoundHuman-GEM MAR07160Inferred only
CHEBI:16497 is a substrate of POLE4CompoundHuman-GEM MAR07160Inferred only
dCTP is a substrate of POLE4CompoundHuman-GEM MAR07160Inferred only
dTTP is a substrate of POLE4CompoundHuman-GEM MAR07160Inferred only

Reactions

1 reaction

0.3CHEBI:16284+0.2dCTP+0.2CHEBI:16497+0.3dTTPMAM01721n+diphosphate(3-)
Catalysed by POLE4 & POLE3 or POLD1 & POLD2 & POLD3 & POLD4 or POLA1 & POLA2 or POLA1 & POLD1 & POLD2 & POLE2 & POLE

Other names

2 names

Resolves to: POLE4

Also called: DNA polymerase epsilon subunit p12DNA polymerase II subunit 4

← Every protein Find it in the graph →

or POLQ

or POLB

or POLI

or RFC5

or POLK

or POLM

and 5 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus

Human-GEM MAR07160CC BY 4.0Reference data